Effects and interactions of epinephrine, norepinephrine, timolol, and betaxolol on outflow facility in the cynomolgus monkey.
Effects and interactions of epinephrine, norepinephrine, timolol, and betaxolol on outflow facility in the cynomolgus monkey.
复制标题
肾上腺素、去甲肾上腺素、噻吗洛尔和倍他洛尔对食蟹猴流出设施的影响和相互作用。
DOI：
10.1016/s0002-9394(14)75985-9
复制
发表时间：
1990
影响因子：
4.2
通讯作者：
Kaufman,PL
中科院分区：
文献类型：
--
作者：
Robinson,JC;Kaufman,PL
Total outflow facility was determined in cynomolgus monkeys by two-level constant pressure perfusion. Topical epinephrine increased facility by 30% to 35% three to four hours after dosing, whether given as a single 600-μg dose or as twice daily 600-μg doses for three days. A single 5.5-μg intracameral dose of epinephrine or norepinephrine increased facility by 65% to 70% three to four hours after dosing. A single 180-μg topical dose of timolol or betaxolol had no effect on facility three to four hours later. Timolol pretreatment prevented the facility-increasing effect of both topical epinephrine and intracameral norepinephrine, but betaxolol pretreatment prevented neither. These findings indicate that no cumulative facility-increasing effect of epinephrine, beyond the acute (three hour) facility-increasing effect, develops within three days; there may be a facility-decreasing effect of large topical epinephrine doses on the vascular structures external to the trabecular meshwork; there is no, or only subthreshold, facility-affecting ambient β-adrenergic tone in the meshwork; and the facility-increasing effect of both epinephrine and norepinephrine is mediated by β2-adrenergic receptors in the trabecular endothelium.
