Differential dominance of pleiotropic loci for mouse skeletal traits.
Differential dominance of pleiotropic loci for mouse skeletal traits.
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小鼠骨骼特征多效性基因座的差异显性。
DOI：
10.1111/j.1558-5646.2009.00681.x
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Cheverud,JamesM
中科院分区：
文献类型：
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作者：
Kenney-Hunt,JaneP;Cheverud,JamesM
“差异显性”一词描述了多效性位点的显性效应在性状之间的差异。表型上的定向选择可导致差异显性多效位点的平衡选择。即使没有任何个体的显性性状，某些性状的线性组合也会在显示差异显性的位点上显示显性。在自然种群中发现高水平的杂合性，部分原因可能是多变量显性。我们在92个数量性状位点（QTL）上检测了70个小鼠骨骼性状的差异显性。我们的研究结果表明，在多效位点上存在中等到强烈的加性和显性效应，低水平的个体-性状显性和普遍的多变量显性。多变量显性影响6%至81%的形态空间，平均为32%。多变量显性倾向于在多效位点上影响更大比例的形态空间，并对多个性状产生拮抗作用（42%）。我们得出结论，多元显性是常见的，应该在模型和遗传变异在可进化性中的作用的实证研究中加以考虑。
The term “differential dominance” describes the situation in which the dominance effects at a pleiotropic locus vary between traits. Directional selection on the phenotype can lead to balancing selection on differentially dominant pleiotropic loci. Even without any individual overdominant traits, some linear combination of traits will display overdominance at a locus displaying differential dominance. Multivariate overdominance may be responsible, in part, for high levels of heterozygosity found in natural populations. We examine differential dominance of 70 mouse skeletal traits at 92 quantitative trait loci (QTL). Our results indicate moderate to strong additive and dominance effects at pleiotropic loci, low levels of individual-trait overdominance, and universal multivariate overdominance. Multivariate overdominance affects a range of 6% to 81% of morphospace, with a mean of 32%. Multivariate overdominance tends to affect a larger percentage of morphospace at pleiotropic loci with antagonistic effects on multiple traits (42%). We conclude that multivariate overdominance is common and should be considered in models and in empirical studies of the role of genetic variation in evolvability.