High expression of DEK is associated with poor prognosis in hepatocellular carcinoma
High expression of DEK is associated with poor prognosis in hepatocellular carcinoma
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DOI：
10.14670/hh-18-125
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发表时间：
2019-11-01
影响因子：
2
通讯作者：
Kim, Baek-Hui
中科院分区：
文献类型：
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作者：
Lee, Soo Yeon;Jung, Wonkyung;Kim, Baek-Hui
Dek是一种癌基因，已被鉴定为dek-can融合基因的一部分。DEK通过WNT信号在肿瘤发生中发挥作用，并通过细胞周期蛋白依赖的激酶信号诱导细胞增殖。DEK在肝细胞癌中的过度表达已有报道，但其临床意义尚不清楚。这项研究纳入了221例肝细胞癌患者。免疫组织化学染色检测DEK蛋白的表达。CDK4、细胞周期蛋白D1、WNT10b、E-钙粘蛋白和β-连环蛋白免疫组织化学染色，并进行相关性分析。分析临床病理因素与DEK表达的关系。DEK表达阳性率为44.8%(99/221)。DEK的表达与临床病理因素有关，包括Edmondson-Steiner分级、血管栓子的存在和多发性(p
DEK is an oncogene that has been identified as part of the DEK-CAN fusion gene. DEK plays a role in carcinogenesis through WNT signaling and induces cell proliferation through cyclin-dependent kinase signaling. DEK overexpression has been reported in HCC, but the clinical significance is unclear. This study enrolled 221 cases of HCC. The expression of DEK protein was evaluated by immunohistochemical staining. Cdk4, cyclin D1, Wnt10b, E-cadherin, and beta-catenin were also immunohistochemically stained and analyzed for correlation. The association of clinicopathologic factors with DEK expression was analyzed. DEK expression was observed in 44.8% (99/221) of cases. DEK expression showed a statistical association with clinicopathologic factors, including Edmondson-Steiner grade, presence of vascular emboli, and multiplicity (p