Connectivity and expression in protein networks: Proteins in a complex are uniformly expressed
Connectivity and expression in protein networks: Proteins in a complex are uniformly expressed
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DOI：
10.1103/physreve.73.031909
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发表时间：
2006-03-01
影响因子：
2.4
通讯作者：
Eisenberg, E
中科院分区：
文献类型：
--
作者：
Carmi, S;Levanon, EY;Eisenberg, E
我们探索蛋白质-蛋白质相互作用网络和相互作用蛋白质的表达之间的相互作用。它表明，相互作用的蛋白质表达在显着更相似的细胞浓度。这在很大程度上是由于蛋白质复合物的一部分相互作用对。我们解决了一个通用的复杂的形成模型，并明确表明，复杂的形式最有效的时候，他们的成员有大致相同的浓度。因此，观察到的相互作用蛋白浓度的相似性可归因于复合物形成效率的优化。
We explore the interplay between the protein-protein interactions network and the expression of the interacting proteins. It is shown that interacting proteins are expressed in significantly more similar cellular concentrations. This is largely due to interacting pairs which are part of protein complexes. We solve a generic model of complex formation and show explicitly that complexes form most efficiently when their members have roughly the same concentrations. Therefore, the observed similarity in interacting protein concentrations could be attributed to optimization for efficiency of complex formation.