Quantitative in-line monitoring of powder blending by near infrared reflection spectroscopy
Quantitative in-line monitoring of powder blending by near infrared reflection spectroscopy
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DOI：
10.1016/s0032-5910(01)00456-9
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发表时间：
2002-03-11
影响因子：
5.2
通讯作者：
Folestad, S
中科院分区：
文献类型：
--
作者：
Berntsson, O;Danielsson, LG;Folestad, S
提出了一种原位定量测量粉末混合物化学含量的方法。通过近红外光谱(NIR)和光纤漫反射探头插入搅拌机中的粉末，可以在加工过程中确定粉末混合物的含量。用一种简化的多元校正方法从近红外光谱中确定粉末含量。利用这种方法，可以离线制备和分析校准样品。该方法可用于实时监测粉末混合物的含量和均匀性，从而在开发、放大和生产过程中评估粉末混合等粉末处理操作的性能。本文用傅里叶变换-近红外光谱仪监测了由粗粉(d>；300um)和细粉(d<；200um)组成的分离粉混合物在对流混合器(Nauta Mixer)中的混合情况。既使用了小型实验室规模的搅拌机，也使用了大型生产规模的搅拌机。结果表明，通过高速采样，可以在加工过程中对混合物的平均含量和分布进行评估。实验内容随过程时间的变化曲线与Nauta混合器内混合的理论模拟模型吻合较好。(C)2002 Elsevier Science B.V.保留所有权利。
A method for quantitative in-situ measurements of the chemical content of powder mixtures is presented. By means of near infrared spectroscopy (NIR) and a fiber-optic diffuse reflection probe inserted into the powder in the blender, determinations of the powder mixture content can be made during processing. A simplified methodology for multivariate calibration is used to determine the powder content from the NIR spectra. With this methodology, calibration samples are prepared and analyzed off-line. The presented method can be used to monitor the content and the homogeneity of powder mixtures in real time and thus to assess the performance of powder handling operations, such as powder mixing, during development, scale-up and production. In this paper, an Fourier transform (FF)-NIR spectrometer was used to monitor the mixing of a segregating powder mixture, consisting of a coarse (d > 300 mum) and a fine powder (d < 200 mum), in a convective mixer (Nauta mixer). Both a small laboratory-scale and a large production-scale mixer were used. It is demonstrated that by high-speed sampling, both the average content and the distribution of the mixture content can be assessed during processing. The experimental content vs. process time trajectories are in good agreement with a theoretical simulation model for blending in Nauta mixers. (C) 2002 Elsevier Science B.V. All rights reserved.