Characteristics of Corneal Endotheliitis among Different Viruses by in Vivo Confocal Microscopy
Characteristics of Corneal Endotheliitis among Different Viruses by in Vivo Confocal Microscopy
复制标题
体内共聚焦显微镜观察不同病毒角膜内皮炎的特征
DOI：
10.1080/09273948.2019.1678648
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发表时间：
2019-10-14
影响因子：
3.3
通讯作者：
Hong, Jing
中科院分区：
文献类型：
--
作者：
Peng, Rong-Mei;Guo, Yu-Xin;Hong, Jing
摘要目的：为探讨不同病毒感染角膜内皮炎的细胞形态学特征及变化，采用活体共聚焦显微镜（IVCM）对44例（44只眼）HSV、VZV、CMV和EBV感染角膜内皮炎患者的角膜共聚焦图像进行了回顾性研究。结果：44只正常眼角膜共聚焦图像中，巨细胞病毒20例，单纯疱疹病毒8例，水痘带状疱疹病毒10例，EB巴尔病毒6例。除了基底下神经的长度和朗格汉斯细胞密度外，不同病毒之间的评价结构没有差异。除猫头鹰眼形态外，不同病毒间内皮细胞层的差异不显著。结论：ICVM可辅助诊断内皮炎。结果表明，除猫头鹰眼形态、基底下神经长度和朗格汉斯细胞密度不同外，不同病毒对角膜的影响没有差异
ABSTRACT Objectives: To explore the cellular morphological characteristics and changes in corneal endotheliitis among different viruses by in vivo confocal microscopy (IVCM).Methods: Corneal confocal images of 44 eyes of 44 patients with HSV, VZV, CMV and EBV corneal endotheliitis were studied retrospectively. Corneal confocal images of 44 normal eyes were used as controls.Results: The pathogens included cytomegalovirus (n = 20), herpes simplex virus (n = 8), varicella zoster virus (n = 10), and Epstein Barr virus (n = 6). There were no differences in the evaluated structures among the different viruses except for the lengths of the subbasal nerves and Langerhans cell densities. Deviations in endothelial cell layers were not significant among different viruses except for owl’s eye morphology.Conclusion: ICVM can assist in diagnosing endotheliitis. The results demonstrate that changes in the cornea were not different among the various viruses except for owl’s eye morphology, the lengths of the subbasal nerves and Langerhans cell densities