Caffeic Acid Phenethyl Ester Suppresses the Production of Adipocytokines, Leptin, Tumor Necrosis Factor -Alpha and Resistin, during Differentiation to Adipocytes in 3T3-L1 Cells
Caffeic Acid Phenethyl Ester Suppresses the Production of Adipocytokines, Leptin, Tumor Necrosis Factor -Alpha and Resistin, during Differentiation to Adipocytes in 3T3-L1 Cells
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DOI：
10.1248/bpb.34.490
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发表时间：
2011-04-01
影响因子：
2
通讯作者：
Ikeda, Katsumi
中科院分区：
文献类型：
--
作者：
Juman, Sachiko;Yasui, Naomi;Ikeda, Katsumi
我们先前报道了咖啡酸苯乙酯（CAPE）通过抑制过氧化物酶体增殖物激活受体（PPAR）γ、CCAAT/增强子结合蛋白（C/EBP）α、脂肪酸合酶（Fas）和脂肪细胞特异性脂肪酸结合蛋白2（aP 2）表达来抑制3 T3-L1向脂肪细胞的分化（Juman等人，Biol. Pharm. Bull.，33，1484-1488（2010））。在本研究中，我们证实了CAPE对甘油-3-磷酸脱氢酶（GPDH）活性增加和胰岛素受体底物1（IRS-1）增加具有抑制作用。我们的数据显示，50 μ M CAPE治疗显著降低了瘦素水平（p
We previously reported that caffeic acid phenethyl ester (CAPE) suppresses 3T3-L1 differentiation to adipocytes through the inhibition of peroxisome proliferator-activated receptor (PPAR) gamma, CCAAT/enhancer-binding protein (C/EBP) alpha, fatty acid synthase (Fas) and adipocytes-specific fatty acid binding protein 2 (aP2) expressions (Juman et al., Biol. Pharm. Bull., 33, 1484-1488 (2010)). In the present study, we confirmed that CAPE had inhibitory effects on increased glycerol-3-phosphate dehydrogenase (GPDH) activity and an increased insulin receptor substrate 1 (IRS-1). Our data show that treatment with 50 mu M CAPE significantly reduced the levels of leptin (p