CODON PREFERENCE REFLECTS MISTRANSLATIONAL CONSTRAINTS - A PROPOSAL
CODON PREFERENCE REFLECTS MISTRANSLATIONAL CONSTRAINTS - A PROPOSAL
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DOI：
10.1093/nar/16.9.4111
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发表时间：
1988-05-11
影响因子：
14.9
通讯作者：
MCPHERSON, DT
中科院分区：
文献类型：
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作者：
MCPHERSON, DT
在观察到精氨酸在选择性差的密码子arg-AGA处的赖氨酸错误掺入之后，大肠杆菌中高表达mRNA的密码子使用模式的比较为主要密码子偏好受到误译限制的提议提供了基础。此外，密码子被利用以及排列以提供亲水性保守氨基酸作为由误译事件引起的最可能的替换。
Following the observation of lysine for arginine misincorporation at the poor choice codon arg-AGA, a comparison of codon usage patterns for highly expressed mRNA''s in Escherichia coli provides a basis for the proposal that the major codon preference is subject to mistranslational constraints. In addition, the codon are utilized, as well as arranged, to provide a hydropathically conservative amino acid as the most probable replacement resulting from a mistranslational event.