RKIP inhibits NF-kappaB in cancer cells by regulating upstream signaling components of the IkappaB kinase complex.
RKIP inhibits NF-kappaB in cancer cells by regulating upstream signaling components of the IkappaB kinase complex.
复制标题
DOI：
10.1016/j.febslet.2009.12.051
复制
发表时间：
2010-02-19
期刊：
影响因子：
3.5
通讯作者：
Yeung KC
中科院分区：
文献类型：
--
作者：
Tang H;Park S;Sun SC;Trumbly R;Ren G;Tsung E;Yeung KC
RKIP首先被鉴定为Raf-MEK-ERK信号通路的抑制剂。还发现RKIP在NF-ΚB B通路中起重要作用。遗传学和生物化学研究表明RKIP作为一种支架蛋白，促进IκB被上游激酶磷酸化。然而，与人们对支架蛋白的预期相反，我们的结果表明RKIP对NF-ΚB B转录活性具有总体抑制作用.由于NF-ΚB B靶基因表达受到负调控，包括负调控因子的最佳诱导，我们的数据支持RKIP通过快速诱导NF-κ B B活化抑制剂的表达和合成，经由自动调节反馈环抑制NF-κ B B活性的假设。
RKIP was first identified as an inhibitor of the Raf-MEK-ERK signaling pathway. RKIP was also found to play an important role in the NF-ΚB pathway. Genetic and biochemical studies demonstrated that RKIP functioned as a scaffold protein facilitating the phosphorylation of IκB by upstream kinases. However, contrary to what one would expect of a scaffold protein, our results show that RKIP has an overall inhibitory effect on the NF-ΚB transcriptional activities. Since NF-ΚB target gene expression is subject to negative regulation involving the optimal induction of negative regulators, our data support a hypothesis that RKIP inhibits NF-ΚB activity via the auto-regulatory feedback loop by rapidly inducing the expression and synthesis of inhibitors of NF-ΚB activation.
登录
查看更多内容
影响因子：
30.5
作者：
Sato, S;Sanjo, H;Akira, S
通讯作者：
Akira, S
影响因子：
5.3
作者：
Yeung, K;Janosch, P;Kolch, W
通讯作者：
Kolch, W
DOI：
10.1073/pnas.94.24.12792
发表时间：
1997-11-25
影响因子：
11.1
作者：
Michaud, NR;Therrien, M;Morrison, DK
通讯作者：
Morrison, DK
影响因子：
5.3
作者：
Yeung, KC;Rose, DW;Sedivy, JM
通讯作者：
Sedivy, JM
影响因子：
4.8
作者：
Chatterjee, D;Bai, Y;Yeung, KC
通讯作者：
Yeung, KC