Cosmetic color improvement of the nipple-areola complex by optimal use of tretinoin and hydroquinone
Cosmetic color improvement of the nipple-areola complex by optimal use of tretinoin and hydroquinone
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DOI：
10.1046/j.1524-4725.2002.02097.x
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发表时间：
2002-12-01
影响因子：
2.4
通讯作者：
Iga, T
中科院分区：
文献类型：
--
作者：
Yoshimura, K;Momosawa, A;Iga, T
背景一个成功的治疗，以改善颜色的乳头乳晕复合体（NAC）从来没有报道，虽然妇女寻求更有吸引力的彩色NAC的数量不小。确定我们的漂白方案对NAC美容改善的有效性。治疗方案包括两个阶段：漂白阶段（4-8周）和愈合阶段（4-6周）。0.2-0.4%维A酸水凝胶与5%氢醌、7%乳酸软膏联合应用，每日2次。维甲酸用小的棉花涂抹器涂抹到NAC上，而对苯二酚广泛应用于NAC区域以外。在NAC颜色得到充分改善后，停止应用维甲酸，并在愈合期继续单独应用氢醌，直至反应性红斑消除。15名女性患者参与了这项研究。平均治疗时间为16.6周。根据医生的估计，12名患者（80%）的NAC颜色得到改善，11名患者（73%）对最终结果感到满意。4例患者在间隔1个月应用维甲酸后重复治疗：2例希望进一步改善颜色，2例进行第二疗程以治疗第一疗程引起的周围丘的炎症后色素沉着过度。在迄今为止可用的治疗中，这种方法似乎对NAC颜色的美容改善最有效。
BACKGROUND. A successful treatment to improve the color of nipple-areola complex (NAC) has never been reported, although the number of women seeking the more attractively colored NAC is not small.OBJECTIVE. To determine the effectiveness of our bleaching protocol for cosmetic improvement of the NAC.METHODS. The protocol was composed of two phases: bleaching phase (4-8 weeks) and healing phase (4-6 weeks). 0.2-0.4% tretinoin aqueous gel was applied concomitantly with 5% hydroquinone, 7% lactic acid ointment for bleaching twice a day. Tretinoin was applied to the NAC with a small cotton applicator, while hydroquinone was widely applied beyond the NAC area. After obtaining sufficient improvement in NAC color, the application of tretinoin was discontinued and hydroquinone alone was continually applied in the healing phase until the reactive erythema was eliminated. Fifteen female patients were involved in this study.RESULTS. The average treatment period was 16.6 weeks. Improvement of NAC color was obtained in 12 patients (80%) by the physician's estimation, and 11 patients (73%) satisfied with their final results. The treatment was repeated after a 1-month interval of tretinoin application in 4 patients: 2 desired further improvement in color, and 2 had the second course conducted to treat the postinflammatory hyperpigmentation on the surrounding mound induced by the first course.CONCLUSION. This approach appeared to be most effective for cosmetic improvement of NAC color among treatments available so far.