Anti-Glioma Effect with Targeting Therapy Using Folate Modified Nano-Micelles Delivery Curcumin
Anti-Glioma Effect with Targeting Therapy Using Folate Modified Nano-Micelles Delivery Curcumin
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使用叶酸修饰的纳米胶束递送姜黄素进行靶向治疗的抗神经胶质瘤作用
DOI：
10.1166/jbn.2020.2878
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发表时间：
2020-01-01
影响因子：
2.9
通讯作者：
Liu, Jiagang
中科院分区：
文献类型：
--
作者：
He, Yihong;Wu, Cong;Liu, Jiagang
靶向药物递送系统目前已在癌症治疗中显示出相当大的潜在临床益处。姜黄素通过促进细胞凋亡和抑制细胞增殖而成为治疗多形性胶质母细胞瘤的候选抗肿瘤药物。本研究以姜黄素、MPEG-PLA和Fa-PEG-PLA为载体，通过自组装技术构建了一种新型的靶向给药系统。与游离姜黄素和Cur/MPEG-PLA相比，Cur/Fa-PEG-PLA能显著抑制GL 261细胞的生长，促进细胞凋亡。此外，姜黄素/Fa-PEG-PLA复合物对荷瘤小鼠进行处理后，发现姜黄素/Fa-PEG-PLA复合物对荷瘤小鼠的肿瘤生长有明显的抑制作用。在皮下和颅内肿瘤模型中的肿瘤生长通过抑制血管生成和促进体内细胞凋亡而被抑制。姜黄素/Fa-PEG-PLA纳米粒有望成为治疗GBM的新药物。
Targeted drug delivery systems have currently demonstrated considerable potential clinical benefits in cancer treatment. Curcumin has become a candidate anti-tumor drug for the therapy of glioblastoma multiforme (GBM) by increasing cell apoptosis and suppressing cell proliferation. In current research, we explored a novel targeted drug delivery system with a self-assembly measure by curcumin, MPEG-PLA and Fa-PEG-PLA. Compared with free curcumin and Cur/MPEG-PLA, Cur/Fa-PEG-PLA can remarkably suppress the growth of GL261 cells and promote apoptotic rate. Moreover, after the procession of tumor-bearing mice with curcumin/Fa-PEG-PLA complex. tumor growth in subcutaneous and intracranial tumor models were repressed via suppressing angiogenesis and facilitating apoptosis in vivo. The Curcumin/Fa-PEG-PLA nanoparticle may be a novel drug for the therapy of GBM.