Combined exercise training reduces fatigue and modulates the cytokine profile of T-cells from multiple sclerosis patients in response to neuromediators
Combined exercise training reduces fatigue and modulates the cytokine profile of T-cells from multiple sclerosis patients in response to neuromediators
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DOI：
10.1016/j.jneuroim.2016.02.014
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发表时间：
2016-04-15
影响因子：
3.3
通讯作者：
Bento, Cleonice A. M.
中科院分区：
文献类型：
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作者：
Alvarenga-Filho, Helcio;Sacramento, Priscila M.;Bento, Cleonice A. M.
疲劳是多发性硬化症 (MS) 的一种常见且致残的症状，多发性硬化症是一种典型的 Th1 和 Th17 介导的自身免疫性疾病。目前尚无有效的药物治疗疲劳的方法，但一些报告指出体力活动对控制多发性硬化症患者的疲劳有有益的作用。由于多发性硬化症和疲劳都与细胞因子网络产生失调有关，本研究的目的是评估由 12 周一系列普拉提和有氧运动相结合组成的体力活动计划对疲劳严重程度（通过 FSS 确定）和细胞因子产生（通过 ELISA 定量）的影响，该计划来自低残疾（EDSS）多发性硬化症患者（n = 08）的 T 细胞
Fatigue is a common and disabling symptom of multiple sclerosis (MS), a classical Th1- and Th17-mediated autoimmune disease. There is no effective pharmacological treatment for fatigue, but some reports point towards beneficial effects of physical activity on management of the fatigue in MS patients. As both MS and fatigue have been associated with dysregulated cytokine network production, the objective of the present study was to evaluate the impact of a physical activity program consisting of a 12-week series of combining Pilates and aerobic exercises on fatigue severity, determined by FSS, and cytokine production, quantified by ELISA, by T cells from MS patients (n = 08) with low disability (EDSS