Type 1 Diabetes in Acute Pancreatitis Consortium: From Concept to Reality.
Type 1 Diabetes in Acute Pancreatitis Consortium: From Concept to Reality.
复制标题
1型糖尿病急性胰腺炎联盟：从概念到现实。
DOI：
10.1097/mpa.0000000000002073
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发表时间：
2022-07-01
期刊：
影响因子：
2.9
通讯作者：
Andersen, Dana K.
中科院分区：
文献类型：
--
作者：
Serrano, Jose;Laughlin, Maren R.;Bellin, Melena D.;Yadav, Dhiraj;Chinchilli, Vernon M.;Andersen, Dana K.
关键词：
急性胰腺炎(AP)是由胰腺炎症引起的，每年导致美国医院出院30多万人次。虽然葡萄糖耐量异常已被认为是严重急性胰腺炎的并发症，但这种影响被认为是暂时的。最近，对一次或多次AP患者存活下来的24项已发表研究的队列研究和荟萃分析显示，30-40%的患者在AP单次发作的3-4年内发展为糖尿病或糖耐量受损。国家糖尿病、消化和肾脏疾病研究所资助了急性胰腺炎1型糖尿病联盟(T1DAPC)，以对AP发作期间或随后发生糖尿病的情况进行前瞻性观察研究，重点是1型糖尿病(T1D)。资助T1DAPC的关键因素是AP的发病率和流行率的增加，它与AP后T1D和其他形式糖尿病的发展的相关性，其并发症，以及相关的医疗费用。本文介绍了T1DAPC的结构、治理和研究目标。将由T1DAPC进行的DREAM(糖尿病与急性胰腺炎及其机制相关)研究在本期杂志的其他文章中进行了描述。
Acute pancreatitis (AP), resulting from inflammation of the pancreas, accounts for over 300,000 US hospital discharges per year. Although glucose intolerance has been known as a complication of severe AP, this effect was thought to be transient. Recently, cohort studies and meta-analysis of 24 published studies of 1100 patients who survived one or more episodes of AP revealed that 30–40% of patients developed diabetes or impaired glucose tolerance within 3–4 years of even a single episode of AP. The National Institute of Diabetes and Digestive and Kidney Diseases funded the Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC) to undertake a prospective observational study of the occurrence of diabetes during an AP episode or subsequently, with emphasis on type 1 diabetes (T1D). Key factors for funding T1DAPC are the increasing incidence and prevalence of AP, its association with the development of T1D and other forms of diabetes after AP, its complications, and associated health care cost. The T1DAPC structure, governance and research objectives are described in this article. The DREAM (Diabetes RElated to Acute Pancreatitis and its Mechanisms) study to be undertaken by the T1DAPC is described in other articles in this journal’s issue.