Surfactin C inhibits Mycoplasma hyopneumoniae-induced transcription of proinflammatory cytokines and nitric oxide production in murine RAW 264.7 cells
Surfactin C inhibits Mycoplasma hyopneumoniae-induced transcription of proinflammatory cytokines and nitric oxide production in murine RAW 264.7 cells
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DOI：
10.1007/s10529-007-9552-x
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发表时间：
2008-02-01
影响因子：
2.7
通讯作者：
Park, Seung-Chun
中科院分区：
文献类型：
--
作者：
Hwang, Mi-Hyun;Chang, Zhi-Qiang;Park, Seung-Chun
在RAW 264.7细胞中，100 μ g蛋白ml（-1）的完整致病性猪肺炎支原体可诱导促炎细胞因子如环氧合酶（考克斯）-2、肿瘤坏死因子（TNF）-α、白细胞介素（IL）-1、IL-6和诱导型一氧化氮合酶（iNOS）的转录。在用50 μ g/ml的从枯草芽孢杆菌纯化的表面活性素C预处理后，由M.抑制率分别为43%、82%、72%和59%。
Intact pathogenic Mycoplasma hyopneumoniae at 100 mu g protein ml(-1) induced transcription of proinflammatory cytokines such as cyclooxygenase (COX)-2, tumor necrosis factor (TNF)-alpha, interleukin(IL)-1, IL-6 and inducible nitric oxide synthase (iNOS) in RAW 264.7 cells. After pretreatment with 50 mu g surfactin C/ml, purified from Bacillus subtilis, transcription of the COX-2, IL-1 beta, IL-6 and iNOS genes induced by M. hyopneumoniae was inhibited by 43%, 82%, 72% and 59%, respectively.