Structure-function relationships in the vitamin D endocrine system.
Structure-function relationships in the vitamin D endocrine system.
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DOI：
10.1210/edrv-16-2-200
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发表时间：
1995-04
影响因子：
20.3
通讯作者：
R. Bouillon;W. Okamura;A. Norman
中科院分区：
文献类型：
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作者：
R. Bouillon;W. Okamura;A. Norman
I.维生素D内分泌系统研究旨在确定维生素D的分子作用模式，目前正处于顶峰。现在有证据表明，维生素D代谢物在许多细胞过程中，包括钙稳态，免疫，细胞分化和基因转录的调节中起着重要作用。此外，有证据表明维生素D的神经活性形式1 α，25-二羟基维生素D3 [1 α，25（OH）2D3]可能通过基因转录调节以及非基因组途径（其中一些涉及电压门控Ca 2+通道的开放）产生生物学反应。此外，有许多正常状态的病理性破坏的实例，其中维生素D代谢物的药物形式被提议为（潜在）有用的治疗形式，例如肾性骨营养不良、牛皮癣、白血病、乳腺癌和骨质疏松症。B。从维生素到类固醇激素分子维生素D在高等生物系统中的重要性。
I. Vitamin D Endocrine System RESEARCH directed at defining the molecular mode of action of vitamin D is currently at its apex. There is now evidence implicating the essential involvement of vitamin D metabolites in a host of cellular processes, including calcium homeostasis, immunology, cell differentiation, and regulation of gene transcription. Further, there is evidence that the hormonally active form of vitamin D, 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3], may generate biological responses via both regulation of gene transcription as well as via nongenomic pathways, some of which involve opening of voltage-gated Ca2+ channels. In addition, there are many examples of pathological disruption of the normal state in which a drug form of a vitamin D metabolite is proposed to be a (potentially) useful form of treatment, e.g. renal osteodystrophy, psoriasis, leukemia, breast cancer, and osteoporosis. B. From vitamin to steroid hormone The importance of the molecule vitamin D in the biological systems of highe...