Long-term survival and PSA control with radiation and immunotherapy for node positive prostate cancer.

Long-term survival and PSA control with radiation and immunotherapy for node positive prostate cancer.
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DOI:
10.1155/2009/363914
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发表时间:
2009
影响因子:
--
通讯作者:
Gulley J
Gulley J
中科院分区:
其他
文献类型:
--
作者:
Kamrava M;Tsang KY;Madan RA;Kaushal A;Coleman CN;Gulley J

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我们描述了一个淋巴结阳性的前列腺癌患者接受放疗、雄激素剥夺和免疫治疗,长期总生存率和PSA控制。ELISPOT免疫测定研究证明了在开始疫苗治疗之前PSA特异性T细胞,表明这种阳性应答可能与患者的抗肿瘤免疫应答改善、肿瘤免疫原性增加或免疫逃逸途径活化减少有关。进一步评估治疗性癌症疫苗联合放射和激素治疗在前列腺癌的最终管理是必要的。
We describe a patient with node positive prostate cancer treated with radiation, androgen deprivation, and immunotherapy with long-term overall survival and PSA control. ELISPOT immunoassay studies demonstrated PSA specific T-cells prior to starting vaccine therapy suggesting that this positive response may be related to an improved antitumor immune response of the patient, increased immunogenicity of the tumor, or decreased activation of immune escape pathways. Further evaluation of therapeutic cancer vaccines in combination with radiation and hormonal therapy in the definitive management of prostate cancer is warranted.
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