Study of the aggregation of insulin glargine by light scattering.
Study of the aggregation of insulin glargine by light scattering.
复制标题
光散射法研究甘精胰岛素的聚集。
DOI：
10.1002/jps.20609
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发表时间：
2006
影响因子：
3.8
通讯作者：
V. Villari
中科院分区：
文献类型：
--
作者：
R. Coppolino;S. Coppolino;V. Villari
甘精胰岛素（来得时，Aventis Pharma，Deutschland，GmbH）是一种新型长效人胰岛素类似物。胰岛素分子在两个位点的结构修饰改变了其pH值，导致甘精胰岛素在皮下组织的中性环境中沉淀，并形成缓慢吸收到血流中的贮库。本文用光散射法研究了甘精胰岛素的聚集。这项研究表明，在类似生理的pH（即使在低离子强度下）条件下，会发生聚集现象，产生半径为数百纳米的紧凑结构。甘精胰岛素的聚集可能是其原位吸收缓慢的原因，从而可以更好地控制释放。
Insulin glargine (Lantus, Aventis Pharma, Deutschland, GmbH) is a new long-acting human insulin analog. Structural modification of the insulin molecule at two sites alters its pH, causing insulin glargine to precipitate in the neutral environment of subcutaneous tissue and to form a depot that is slowly absorbed into the bloodstream. In this paper insulin glargine aggregation is investigated by light scattering. This study shows that, in a physiologic-like pH (even at low ionic strength) conditions, aggregation phenomena occur, giving rise to compact structures with radius of hundreds of nanometers. The aggregation of insulin glargine can be responsible for its slow in situ absorption allowing for a more controlled release.