Tropisetron alleviate early post-operative pain after gynecological laparoscopy in sevoflurane based general anaesthesia: A randomized, parallel-group, factorial study
Tropisetron alleviate early post-operative pain after gynecological laparoscopy in sevoflurane based general anaesthesia: A randomized, parallel-group, factorial study
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托烷司琼减轻七氟醚全身麻醉妇科腹腔镜手术后早期术后疼痛：一项随机、平行组析因研究
DOI：
10.1002/j.1532-2149.2013.00365.x
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发表时间：
2014-02-01
影响因子：
3.6
通讯作者：
Tian, Y.
中科院分区：
文献类型：
--
作者：
Mei, W.;Li, M.;Tian, Y.
研究背景5-羟色胺-3A(5-HT3A)受体拮抗剂可能具有镇痛作用。这项随机、双盲、安慰剂对照的析因研究验证了5-羟色胺-3A受体拮抗剂托烷司琼可以减轻接受七氟醚或异丙酚麻醉的女性术后疼痛的假设。方法296名接受妇科腹腔镜手术的女性被随机分配到七氟醚或异丙酚麻醉。麻醉诱导后，麻醉师立即静脉注射托烷司琼2 mg或安慰剂。手术后0.5h的静息疼痛评分是主要的结果衡量标准。结果与安慰剂相比，七氟醚麻醉组术后6h内疼痛发生率显著降低(3[2，4]比5[4，5]，P<0.05)。
BackgroundStudies have suggested that 5-hydroxytryptamine-3A (5-HT-3A) receptor antagonists may have analgesic effects. This randomized, double-blind, placebo-controlled, factorial study tested the hypothesis that 5-HT-3A receptor antagonist tropisetron attenuates post-operative pain in women receiving either sevoflurane or propofol based anaesthesia.MethodsTwo hundred and ninety-six women undergoing gynaecological laparoscopies were randomly assigned to be anaesthetized with either sevoflurane or propofol. Immediately after the induction of anaesthesia, the anaesthesiologist administered either tropisetron 2mg or a placebo intravenously. Pain score at rest at 0.5h post-operatively reported using a numerical rating scale was the primary outcome measure. The secondary outcome measures included pain score at rest every 2h within the first 24h post-operatively, duration of post-anaesthesia care unit stay, incidence of post-operative nausea and vomiting, the incidence of shivering and score of the Quality of Recovery Score 40.ResultsCompared with placebo, tropisetron produced a statistically significant decrease on pain report within the first 6h post-operatively in the sevoflurane-based anaesthesia group (3 [2, 4] vs. 5 [4, 5], p