Changes in Hemodynamic Response Function Resulting From Chronic Alcohol Consumption.
Changes in Hemodynamic Response Function Resulting From Chronic Alcohol Consumption.
复制标题
长期饮酒导致血流动力学反应功能的变化。
DOI：
10.1111/acer.14327
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
McCaul,MaryE
中科院分区：
文献类型：
--
作者：
Desmond,JohnE;Rice,LauraC;Cheng,DominicT;Hua,Jun;Qin,Qin;Rilee,JessicaJ;Faulkner,MonicaL;Sheu,Yi-Shin;Mathena,JoannaR;Wand,GaryS;McCaul,MaryE
功能磁共振成像（fMRI）任务相关分析依赖于对大脑血流动力学反应函数（HRF）的估计来模拟大脑对事件的反应。虽然在急性饮酒后发现了HRF的变化，但长期大量饮酒对HRF的影响尚未被探讨，并且在慢性酒精使用障碍（AUD）的fMRI分析中估计每个人HRF的潜在益处或缺陷尚不清楚。方法AUD患者和对照组（CTL）接受结构、功能和血管扫描。在fMRI过程中，参与者被提示轻敲手指，并从运动皮层提取平均反应。对这些HRF进行曲线拟合，将其建模为两个gamma分布的差值，并分别从第一个和第二个gamma分布的平均值计算HRF的主峰和底峰的时间发生。结果方差分析和回归分析发现，HRF过低的时间随着总饮酒量的增加而显著增加。尽管运动皮层的灰质体积随着终生饮酒而减少，但这并不足以解释时间变化不足，运动皮层中测量的血管因子在各组之间没有差异。对CTL组和AUD组使用定制和规范hrf进行随机效应分析的比较显示，与CTL组的规范hrf相比，定制hrf在整个大脑中的效果更好。对于AUD受试者，除了基底神经节外，其他情况也一样。结论：这些发现表明，过度饮酒与HRF过低的变化有关。HRF的变化可能为终身饮酒对脑功能的影响提供一种可能的生物标志物。HRF形貌的变化影响fMRI激活测量，受试者特异性HRF通常改善fMRI激活结果。
BackgroundFunctional MRI (fMRI) task‐related analyses rely on an estimate of the brain's hemodynamic response function (HRF) to model the brain's response to events. Although changes in the HRF have been found after acute alcohol administration, the effects of heavy chronic alcohol consumption on the HRF have not been explored, and the potential benefits or pitfalls of estimating each individual's HRF on fMRI analyses of chronic alcohol use disorder (AUD) are not known.MethodsParticipants with AUD and controls (CTL) received structural, functional, and vascular scans. During fMRI, participants were cued to tap their fingers, and averaged responses were extracted from the motor cortex. Curve fitting on these HRFs modeled them as a difference between 2 gamma distributions, and the temporal occurrence of the main peak and undershoot of the HRF was computed from the mean of the first and second gamma distributions, respectively.ResultsANOVA and regression analyses found that the timing of the HRF undershoot increased significantly as a function of total lifetime drinking. Although gray matter volume in the motor cortex decreased with lifetime drinking, this was not sufficient to explain undershoot timing shifts, and vascular factors measured in the motor cortex did not differ among groups. Comparison of random‐effects analyses using custom‐fitted and canonical HRFs for CTL and AUD groups showed better results throughout the brain for custom‐fitted versus canonical HRFs for CTL subjects. For AUD subjects, the same was true except for the basal ganglia.ConclusionsThese findings suggest that excessive alcohol consumption is associated with changes in the HRF undershoot. HRF changes could provide a possible biomarker for the effects of lifetime drinking on brain function. Changes in HRF topography affect fMRI activation measures, and subject‐specific HRFs generally improve fMRI activation results.