POOR APPLICABILITY OF THE FRIEDEWALD FORMULA IN THE ASSESSMENT OF SERUM LDL CHOLESTEROL FOR CLINICAL PURPOSES
POOR APPLICABILITY OF THE FRIEDEWALD FORMULA IN THE ASSESSMENT OF SERUM LDL CHOLESTEROL FOR CLINICAL PURPOSES
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DOI：
10.1016/0009-9120(94)00095-d
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发表时间：
1995-06-01
影响因子：
2.8
通讯作者：
IMPIVAARA, O
中科院分区：
文献类型：
--
作者：
MARNIEMI, J;MAKI, J;IMPIVAARA, O
目的：验证Friedewald公式估算血清低密度脂蛋白(LDL)胆固醇浓度的准确性。方法：采用超速离心法分离全国健康调查样本(n=1215)血清高密度脂蛋白和低密度脂蛋白胆固醇，对公式进行修正。结果：不同受试者的公式差异较小。原始的FFriedewald公式的准确性很差；在大约36%的受试者中，与超速离心法获得的结果相比，误差超过5%。通过应用目前推荐的冠心病风险分类，当用任何公式计算低密度脂蛋白胆固醇时，高比例(5%-28%)的受试者被归入错误的冠心病风险类别。在高血清甘油三酯水平时，错误分类尤其常见。结论：我们得出结论：在将受试者归类为冠心病风险类别时，即使是最准确的低密度脂蛋白胆固醇计算方法也应该谨慎使用。对于高甘油三酯血症的受试者，这些计算公式可能根本不应该使用。
Objective: To determine the accuracy of the estimation of serum low-density lipoprotein (LDL) cholesterol concentration by the Friedewald formula.Methods: Modifications of the calculation formula are presented on the basis of ultracentrifugal separation of serum high-density lipoprotein and LDL cholesterol in the specimens collected (n = 1215) in a nationwide health survey.Results: The formulas obtained from different subject groups differed relatively little from each other. The accuracy of the original Ffriedewald formula was poor; in about 36% of the subjects the error was more than 5% compared with ultracentrifugally obtained results. By applying the currently recommended coronary heart disease (CHD) risk categorizations, high proportions (5%-28%) of the subjects were classified into wrong CHD risk categories when LDL cholesterol was calculated with any of the formulas. At high serum triglyceride levels, misclassifications were especially common.Conclusions: We conclude that even the most accurate LDL cholesterol calculation methods should be used with caution while classifying subjects into categories of CHD risk. In hypertriglyceridemic subjects, the calculation formulas probably should not be used at all.