Synthesis of biomimetic segmented polyurethanes as antifouling biomaterials
Synthesis of biomimetic segmented polyurethanes as antifouling biomaterials
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DOI：
10.1016/j.actbio.2011.10.024
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发表时间：
2012-02-01
影响因子：
9.7
通讯作者：
Piozzi, A.
中科院分区：
文献类型：
--
作者：
Francolini, I.;Crisante, F.;Piozzi, A.
控制蛋白质、细胞和细菌在生物材料表面上的非特异性吸附对于开发具有特定性能水平的医疗器械至关重要。在控制材料表面和生物组织之间相互作用的策略中，将非污染聚合物固定在生物材料表面以及合成所谓的仿生聚合物被认为是引发特定细胞反应的有前途的方法。在本研究中，为了获得能够预防与使用血液接触医疗器械相关的感染性和血栓性并发症的材料，合成了拟肝素嵌段聚氨酯并对其进行了充分表征。具体而言，已知负责肝素的生物活性的硫酸酯或氨基磺酸酯基团被引入羧基化聚氨酯的侧链中。由于这些基团的引入，所获得的聚合物具有更高的硬/软相分离（较低的玻璃化转变温度）和更大的亲水性比原始聚合物。此外，合成的聚合物能够显着延迟活化部分凝血活酶的时间，这增加了血液相容性相关的聚合物的亲水性和存在的-SO 3 H基团。最后一个特征也是这些仿生聚合物防止表皮葡萄球菌菌株粘附的能力的原因。(C)2011 Acts Materialia Inc.由爱思唯尔有限公司出版。保留所有权利。
Controlling the non-specific adsorption of proteins, cells and bacteria onto biomaterial surfaces is of crucial importance for the development of medical devices with specific levels of performance. Among the strategies pursued to control the interactions between material surfaces and biological tissues, the immobilization of non-fouling polymers on biomaterial surfaces as well as the synthesis of the so-called biomimetic polymers are considered promising approaches to elicit specific cellular responses. In this study, in order to obtain materials able to prevent infectious and thrombotic complications related to the use of blood-contacting medical devices, heparin-mimetic segmented polyurethanes were synthesized and fully characterized. Specifically, sulfate or sulfamate groups, known to be responsible for the biological activity of heparin, were introduced into the side chain of a carboxylated polyurethane. Due to the introduction of these groups, the obtained polymers possessed a higher hard/soft phase segregation (lower glass transition temperatures) and a greater hydrophilicity than the pristine polymer. In addition, the synthesized polymers were able to significantly delay the activated partial thromboplastin time, this increased hemocompatibility being related both to polymer hydrophilicity and to the presence of the -SO3H groups. This last feature was also responsible for the ability of these biomimetic polymers to prevent the adhesion of a strain of Staphylococcus epidermidis. (C) 2011 Acts Materialia Inc. Published by Elsevier Ltd. All rights reserved.