Autophagy defends cells against invading group a Streptococcus
Autophagy defends cells against invading group a Streptococcus
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DOI：
10.1126/science.1103966
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发表时间：
2004-11-05
期刊：
影响因子：
56.9
通讯作者：
Yoshimori, T
中科院分区：
文献类型：
--
作者：
Nakagawa, I;Amano, A;Yoshimori, T
我们发现，自噬机制可以有效地清除非吞噬细胞内的致病性A组链球菌(GAS)。在从内体逃逸到细胞质后，GAS被自噬体样的隔室所包裹，并在这些隔室与溶酶体融合时被杀死。在自噬缺陷的ATG5(-/-)细胞中，GAS存活、增殖并从细胞中释放。因此，自噬机制可以作为一种天生的防御系统来抵御入侵的病原体。
We found that the autophagic machinery could effectively eliminate pathogenic group A Streptococcus (GAS) within nonphagocytic cells. After escaping from endosomes into the cytoplasm, GAS became enveloped by autophagosome-like compartments and were killed upon fusion of these compartments with lysosomes. In autophagy-deficient Atg5(-/-) cells, GAS survived, multiplied, and were released from the cells. Thus, the autophagic machinery can act as an innate defense system against invading pathogens.