Au nanoshell-coated superparamagnetic Fe3O4– silica composite nanoparticles with surfacemodification of an activatable cell-penetrating peptide for tumor-targeted multimode bioimaging and photothermal therapy
Au nanoshell-coated superparamagnetic Fe3O4– silica composite nanoparticles with surfacemodification of an activatable cell-penetrating peptide for tumor-targeted multimode bioimaging and photothermal therapy
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Au纳米壳包覆的超顺磁性Fe3O4-二氧化硅复合纳米颗粒，对可激活的细胞穿透肽进行表面修饰，用于肿瘤靶向多模式生物成像和光热治疗
DOI：
10.1039/c6ra07708k
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发表时间：
2016
期刊：
影响因子：
3.9
通讯作者：
Yang Xiaoying
中科院分区：
文献类型：
--
作者：
Jiang Yunfang;Zhang Qianyu;Liu Xinghua;Chen Yifu;Wang Li;Fu Jingwei;Duan Hongquan;Wang Yinsong;Yang Xiaoying
对与恶性肿瘤和转移密切相关的分子进行高分辨率成像，对肿瘤的临床检测和分期具有重要价值。基于可激活细胞穿透肽(ACPP)对肿瘤部位的选择性穿透能力，制备了包覆金纳米壳(Au纳米壳)的超顺磁性Fe3O4-SiO_2复合纳米颗粒(SSCN)，并用聚乙二醇(PEG)对其进行表面修饰，形成SSCN@AuNSS-PEG-ACPP纳米颗粒，实现肿瘤部位特异性多模生物成像和光热治疗。体内外的一系列表征结果表明，SSCNS@AuNSs-PEG-ACPP纳米粒子具有较高的光热效率、X射线衰减性能和T2弛豫速率。通过体内X射线计算机断层扫描(CT)和磁共振成像(MR)研究SSCNS@AuNSs-PEG-ACPP纳米粒子在肿瘤中的增强积聚。SSCNS@AuNSs-PEG-ACPP纳米粒子结合了超顺磁化、X射线衰减、近红外(NIR)吸收和肿瘤选择性聚集等特性，有望实现肿瘤CT/MR生物成像和光热治疗的同步进行。
High-resolution imaging of molecules intrinsically involved in malignancy and metastasis would be of great value for clinical detection and staging of tumors. Based on the selective cell-penetrating ability in the tumor sites of the activatable cell-penetrating peptide (ACPP), the superparamagnetic Fe3O4–silica composite nanoparticles (SSCNs) coated with Au nanoshells (AuNSs) were prepared and subsequently surface-modified with polyethylene glycol (PEG) conjugated an ACPP to form SSCNs@AuNSs-PEG-ACPP nanoparticles for realizing tumor site-specific multimode bioimaging and photothermal therapy. SSCNs@AuNSs-PEG-ACPP nanoparticles showed high photothermal efficiency, X-ray attenuation property and T2 relaxation rate, which were confirmed by a series of characterizations in vitro and in vivo. The enhanced accumulation of SSCNs@AuNSs-PEG-ACPP nanoparticles in the tumor was investigated by the in vivo X-ray computed tomography (CT) imaging and magnetic resonance (MR) imaging. SSCNs@AuNSs-PEG-ACPP nanoparticles will be likely to realize simultaneous CT/MR bioimaging and photothermal therapy on the tumor by the combination of superparamagnetization, X-ray attenuation property, near-infrared (NIR) absorption and tumor-selected accumulation.