Micro-engineered architected metamaterials for cell and tissue engineering
Micro-engineered architected metamaterials for cell and tissue engineering
复制标题
用于细胞和组织工程的微工程超材料
DOI：
10.1016/j.mtadv.2022.100206
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发表时间：
2022
影响因子：
10
通讯作者：
Ma, Zhen
中科院分区：
文献类型：
--
作者：
Wang, Chenyan;Vangelatos, Zacharias;Grigoropoulos, Costas P.;Ma, Zhen
建筑超材料是建立在重复细胞结构的组装上，由于细胞几何的可调性，表现出前所未有的机械性能。它们已经在光学和电磁场中展示了广泛的应用，最近它们被用作高级组织工程支架。微几何驱动策略扩大了支架特征的设计领域，并能够更准确地操纵细胞-材料相互作用。本文介绍了生物医学工程中最流行的超材料设计，并总结了它们在制备体外模型和体内植入物方面的代表性应用。这些研究证实了超材料在支持机械生物学研究和改善组织替代物功能方面的独特优势。然而，超生物材料的发展需要更详细的研究结构设计和细胞表型之间的关系，以及准确的理论模型。
Architected metamaterials are built upon the assembly of repeating cellular structures, exhibiting unprecedented mechanical properties attributed to the tunability of cellular geometries. They have demonstrated a wide range of applications in the optical and electromagnetic fields, and recently they are employed as advanced tissue engineering scaffolds. The microgeometry-driven strategy enlarges the design domain of scaffold features and enables more accurate manipulation of cell-material interactions. In this review, we introduce the most popular metamaterial designs in biomedical engineering and summarize their representative applications to fabricatein vitromodels andin vivoimplants. These studies validate the unique advantages of metamaterials in supporting mechanobiological studies and improving the functionality of tissue replacements. Nevertheless, the evolution of meta-biomaterials requires more detailed investigations of the relationship between structural designs and cell phenotypes as well as accurate theoretical models.