Caffeinated Coffee Does Not Acutely Affect Energy Intake, Appetite, or Inflammation but Prevents Serum Cortisol Concentrations from Falling in Healthy Men
Caffeinated Coffee Does Not Acutely Affect Energy Intake, Appetite, or Inflammation but Prevents Serum Cortisol Concentrations from Falling in Healthy Men
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DOI：
10.3945/jn.110.137323
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发表时间：
2011-04-01
影响因子：
4.2
通讯作者：
Mantzoros, Christos S.
中科院分区：
文献类型：
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作者：
Gavrieli, Anna;Yannakoulia, Mary;Mantzoros, Christos S.
在这项交叉研究中，我们的目的是调查饮用咖啡因和无咖啡因咖啡对食欲感觉、能量摄入以及食欲、炎症、压力和葡萄糖代谢相关标记物的急性影响。16名健康男性(年龄范围21-39岁；体重指数范围19.7-28.6公斤/米(2))以随机顺序在3个不同的场合接受了一份标准早餐零食，其中包含200毫升的咖啡因咖啡(3毫克咖啡因/公斤体重)、无咖啡因咖啡或水(对照组)。在干预前(-15分钟)和吃早餐后的标准时间点(0、15、30、60、90、120、150和180分钟)，参与者记录他们的食欲感受，并采集血液样本以测量循环血糖、胰岛素、皮质醇以及食欲和炎症相关标记物。在180分钟时，参与者随意吃一顿饭。食欲相关评分、食欲血浆激素反应以及血糖、血清胰岛素、血浆和血清炎症标志物反应没有显示总体干预效果或时间x干预交互作用。自由采食能量摄入量在3种干预措施之间没有差异。然而，血清皮质醇存在显著的干预效应(P=0.04)和时间x干预交互作用(P交互作用=0.02)；咖啡因咖啡干预后皮质醇浓度显著高于对照组，在60 mM及以后。总而言之，通常摄入的咖啡因咖啡量对食欲、能量摄入、葡萄糖代谢和炎症标志物没有短期影响，但它会增加健康男性循环中的皮质醇浓度。J.Nutr.141：703-707,2011。
Our aim in this crossover study was to investigate the acute effects of caffeinated and decaffeinated coffee consumption on appetite feelings, energy intake, and appetite-, inflammation-, stress-, and glucose metabolism-related markers. Sixteen healthy men (age range, 21-39 y; BMI range, 19.7-28.6 kg/m(2)) received in a random order on 3 separate occasions a standard breakfast snack with 200 mL of either caffeinated coffee (3 mg caffeine/kg body weight), decaffeinated coffee, or water (control). Before intervention (-15 min) and at standard time points following breakfast consumption (0, 15, 30, 60, 90, 120, 150, and 180 min), participants recorded their appetite feelings and we collected blood samples for measurements of circulating glucose, insulin, cortisol, and appetite- and inflammation-related markers. At 180 min, participants consumed a meal ad libitum. The appetite-related ratings, the appetite plasma hormonal responses as well as the plasma glucose, serum insulin, and plasma and serum inflammatory marker responses did not show an overall intervention effect or a time x intervention interaction. Ad libitum energy intake did not differ among the 3 interventions. However, a significant intervention effect (P = 0.04) and a time x intervention interaction (P-interaction = 0.02) were found for serum cortisol; cortisol concentrations were significantly higher following the caffeinated coffee intervention, compared to control, at 60 mm and thereafter. In conclusion, the usually consumed amount of caffeinated coffee does not have short-term effects on appetite, energy intake, glucose metabolism, and inflammatory markers, but it increases circulating cortisol concentrations in healthy men. J. Nutr. 141: 703-707, 2011.