Modeling epistasis of quantitative trait loci using Cockerham's model.
Modeling epistasis of quantitative trait loci using Cockerham's model.
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作者：
C. Kao;Z. Zeng
我们使用Cockerham提出的正交对比度来构建一个遗传模型，称为Cockerham模型，用于研究基因间的上位性。研究和讨论了Cockerham模型在连锁平衡和不平衡条件下对上位基因的建模和定位的性质。由于Cockerham模型的正交性，它在遗传方差的分量划分、基因效应的解释和估计以及QTL定位等方面都具有其它模型所不能比拟的优势，从而可以方便地研究基因间的上位性，便于QTL定位。还讨论了上位性QTL定位的问题。用真实的和模拟的例子来说明Cockerham的模型，比较不同的模型，并定位上位性QTL。最后，我们将Cockerham模型推广到多位点，并讨论了它在QTL定位中的应用。
We use the orthogonal contrast scales proposed by Cockerham to construct a genetic model, called Cockerham's model, for studying epistasis between genes. The properties of Cockerham's model in modeling and mapping epistatic genes under linkage equilibrium and disequilibrium are investigated and discussed. Because of its orthogonal property, Cockerham's model has several advantages in partitioning genetic variance into components, interpreting and estimating gene effects, and application to quantitative trait loci (QTL) mapping when compared to other models, and thus it can facilitate the study of epistasis between genes and be readily used in QTL mapping. The issues of QTL mapping with epistasis are also addressed. Real and simulated examples are used to illustrate Cockerham's model, compare different models, and map for epistatic QTL. Finally, we extend Cockerham's model to multiple loci and discuss its applications to QTL mapping.