Effect of saralasin and serum in myohaemoglobinuric acute renal failure of rats.
Effect of saralasin and serum in myohaemoglobinuric acute renal failure of rats.
复制标题
沙拉辛和血清对大鼠肌血红蛋白尿性急性肾衰竭的影响。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
F. Gross
中科院分区：
文献类型：
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作者：
K. Bauereiss;K. Hofbauer;A. Konrads;F. Gross
1. 在无水无食24 h的大鼠中，肌内注射甘油引起急性肾功能衰竭。8小时后，血浆尿素浓度增加了3倍，尽管尿量略有增加。血浆肾素和肾素底物浓度升高。2. 当甘油注射后注入血管紧张素II的竞争性拮抗剂saralasin 8小时后，尿量和血浆尿素与接受生理盐水输注的大鼠相似。3. 给药大鼠血清（4.5 ml h-1 kg-1） 4小时可抑制血浆肾素浓度，但血浆尿素升高的程度与不给药大鼠相同。4. 与血清同时输注时，尿量、尿渗透压和溶质排泄量均增加，血浆尿素升高幅度减小。5. salalasin对甘油引起的急性肾功能衰竭只有在同时更换容量时才有保护作用。
1. In rats deprived of food and water for 24 h acute renal failure was produced by the intramuscular injection of glycerol. Eight hours later plasma urea concentration had increased threefold despite a small rise in urine volume. Plasma concentrations of renin and renin substrate were elevated. 2. When saralasin, a competitive antagonist of angiotensin II, was infused for 8 h after glycerol injection, urine volume and plasma urea were similar to values in rats that had received an infusion of saline. 3. Administration of rat serum (4.5 ml h-1 kg-1) for 4 h suppressed plasma renin concentrations, but plasma urea increased to the same extent as in rats without serum. 4. When saralasin and serum were infused at the same time, urine volume, urine osmolality and solute excretion increased and the rise of plasma urea was diminished. 5. Saralasin has a protective effect against glycerol-induced acute renal failure only when volume is replaced concomitantly.