EXPRESSION AND LOCALIZATION OF MATRIX-DEGRADING METALLOPROTEINASES DURING COLORECTAL TUMORIGENESIS
EXPRESSION AND LOCALIZATION OF MATRIX-DEGRADING METALLOPROTEINASES DURING COLORECTAL TUMORIGENESIS
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DOI：
10.1002/mc.2940100404
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发表时间：
1994-08-01
影响因子：
4.6
通讯作者：
MATRISIAN, LM
中科院分区：
文献类型：
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作者：
NEWELL, KJ;WITTY, JP;MATRISIAN, LM
金属蛋白酶基质溶素广泛表达于恶性结直肠腺癌的上皮性肿瘤细胞。大约50%的良性腺瘤也表达局部低水平的基质溶素。基质分解素-1、基质分解素-3和明胶酶A在几种癌的间质成分中均有表达，而在腺瘤组织中不表达。间质胶原酶和明胶酶B在间歇性腺瘤和癌组织中均有表达，但未检测到基质分解素-2转录本。金属蛋白酶组织抑制因子L基因广泛表达，在腺瘤和癌的上皮和间质细胞中均有表达。这些结果表明基质分解素基因的表达是大肠肿瘤发生的早期事件，基质分解素-L、基质分解素-3和明胶酶A的表达主要是晚期事件。观察到的基因表达模式表明，基质溶素可能参与了肿瘤进展的早期事件，金属蛋白酶家族的多个成员可能协同作用，促进晚期肿瘤的侵袭和转移。(C)1994年Wiley-Liss，Inc.
The metalloproteinase matrilysin is widely expressed in the epithelial tumor cells of malignant colorectal adenocarcinomas. Approximately 50% of benign adenomas also express low levels of matrilysin that is focally localized. The expression of stromelysin-1, stromelysin-3, and gelatinase A was observed in the stromal component of several carcinomas and was not present in adenomatous tissue. The expression of interstitial collagenase and gelatinase B was observed in occasional adenomas and carcinomas Stromelysin-2 transcripts were not detectable in any of the samples examined. Tissue inhibitor of metalloproteinase-l gene expression was widespread and was observed in both epithelial and stromal cells of adenomas and carcinomas. These results indicate that matrilysin gene expression is an early event in colorectal tumorigenesis and that the expression of stromelysin-l, stromelysin-3, and gelatinase A is primarily a late event. The observed gene expression patterns suggest that matrilysin may participate in early events in tumor progression and that multiple members of the metalloproteinase family may work in concert to facilitate late-stage tumor invasion and metastasis. (C) 1994 Wiley-Liss, Inc.