Anxiety Is Associated With Uninvestigated and Functional Dyspepsia (Rome III Criteria) in a Swedish Population-Based Study
Anxiety Is Associated With Uninvestigated and Functional Dyspepsia (Rome III Criteria) in a Swedish Population-Based Study
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DOI：
10.1053/j.gastro.2009.03.039
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发表时间：
2009-07-01
期刊：
影响因子：
29.4
通讯作者：
Agreus, Lars
中科院分区：
文献类型：
--
作者：
Aro, Pertti;Talley, Nicholas J.;Agreus, Lars
背景与目的：罗马III功能性消化不良标准已被修改为包括两种不同的症状：餐后窘迫综合征和上腹痛综合征。我们调查了罗马III标准定义的功能性消化不良亚组中功能性消化不良的危险因素。方法：我们在初级保健环境中进行了一项基于人群的横断面研究(Kalixanda研究)。瑞典北部两个直辖市(n=21,610)的成人随机抽样(n=2860)使用有效的邮寄问卷进行了调查，以评估胃肠道症状(应答率为74.2%；n=2122)。随机选择一组应答者(n=1001)接受食管胃十二指肠镜检查(参与率为73.3%)，包括活检标本采集、幽门螺杆菌培养和血清学检查以及症状评估。结果：在1001名接受胃镜检查的受试者中，202人(20.2%，95%可信区间，17.7-22.7)被归类为未调查的消化不良，157人(15.7%，95%可信区间，13.4-18.0)被归类为功能性消化不良。严重焦虑(医院焦虑和抑郁量表得分；！：11)与未调查的消化不良有关(优势比[OR]，3.01，95%CI，1.39-6.54)，肥胖(体重指数：30 kg/m(2))(OR，1.86；95%CI，1.15-3.01)。重度焦虑与功能性消化不良和餐后窘迫综合征有关(OR值分别为2.56[95%CI，1.06~6.19]和4.35[95%CI，1.81~10.46])，使用非甾体抗炎药的OR值分别为2.49[95%CI，1.29~4.78]和2.75[95%CI，1.38~5.50]。抑郁与任何消化不良组无关。结论：焦虑而不是抑郁与未经调查的消化不良、功能性消化不良和餐后窘迫综合征有关，但与上腹痛综合征无关。
BACKGROUND & AIMS: The Rome III criteria for functional dyspepsia have been changed to include 2 distinct syndromes: postprandial distress syndrome and epigastric pain syndrome. We investigated risk factors for functional dyspepsia among the functional dyspepsia subgroups defined by the Rome III criteria. METHODS: We performed a cross-sectional population-based study in a primary care setting (the Kalixanda Study). A random sample (n = 2860) of the adult population from 2 northern Swedish municipalities (n = 21,610) was surveyed using a validated postal questionnaire to assess gastrointestinal symptoms (response rate, 74.2%; n = 2122). A randomly selected subgroup (n = 1001) of responders was invited to undergo an esophagogastroduodenoscopy (participation rate, 73.3%) including biopsy specimen collection, Helicobacter pylori Culture and serology, and symptom assessments. RESULTS: Of the 1001 subjects examined by endoscopy, 202 (20.2%; 95% confidence interval [CI], 17.7-22.7) were classified as having uninvestigated dyspepsia and 157 (15.7%; 95% CI, 13.4-18.0) as having functional dyspepsia. Major anxiety (Hospital Anxiety and Depression Scale score; !:11) was associated with uninvestigated dyspepsia (odds ratio [OR], 3.01, 95% CI, 1.39-6.54), as was obesity (body mass index; !:30 kg/m(2)) (OR, 1.86; 95% CI, 1.15-3.01). Major anxiety was associated with functional dyspepsia and postprandial distress syndrome (OR of 2.56 [95% CI, 1.06-6.19] and 4.35 [95% CI, 1.81-10.46], respectively), as was use of nonsteroidal anti-inflammatory drugs (OR, 2.49 [95% CI, 1.29-4.78] and 2.75 [95% CI, 1.38-5.50], respectively). Depression was not associated with any dyspepsia group. CONCLUSIONS: Anxiety but not depression is linked to uninvestigated dyspepsia, functional dyspepsia, and postprandial distress syndrome but not to epigastric pain syndrome.