The seed extract of Cassia obtusifolia ameliorates learning and memory impairments induced by scopolamine or transient cerebral hypoperfusion in mice
The seed extract of Cassia obtusifolia ameliorates learning and memory impairments induced by scopolamine or transient cerebral hypoperfusion in mice
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DOI：
10.1254/jphs.fp0061565
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发表时间：
2007-09-01
影响因子：
3.5
通讯作者：
Ryu, Jong Hoon
中科院分区：
文献类型：
--
作者：
Kim, Dong Hyun;Yoon, Byung Hoon;Ryu, Jong Hoon
在本研究中，我们评估了决明子乙醇提取物（COE）对东莨菪碱或短暂双侧颈总动脉闭塞（2 VO）引起的学习和记忆障碍的影响。在东莨菪碱引起的胆碱能功能障碍的研究中，单次COE（25、50或100 mg/kg，p.o.）通过被动回避和Y-迷宫任务测定，给药显著减轻东莨菪碱诱导的认知障碍（P
In the present study, we assessed the effect of the ethanolic extract of the seeds of Cassia obtusifolia (COE) on the learning and memory impairments induced by scopolamine or transient bilateral common carotid artery occlusion (2VO). In a study of the cholinergic dysfunction induced by scopolamine, single COE (25, 50, or 100 mg/kg, p.o.) administration significantly attenuated scopolamine-induced cognitive impairments as determined by the passive avoidance and Y-maze tasks (P