DOES INCREASED GAMMA ACTIVITY IN PATIENTS SUFFERING FROM PARKINSON'S DISEASE COUNTERACT THE MOVEMENT INHIBITING BETA ACTIVITY?
DOES INCREASED GAMMA ACTIVITY IN PATIENTS SUFFERING FROM PARKINSON'S DISEASE COUNTERACT THE MOVEMENT INHIBITING BETA ACTIVITY?
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DOI：
10.1016/j.neuroscience.2013.01.051
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发表时间：
2013-05-01
期刊：
影响因子：
3.3
通讯作者：
Timmermann, L.
中科院分区：
文献类型：
--
作者：
Florin, E.;Erasmi, R.;Timmermann, L.
运动障碍和僵硬是帕金森病（PD）的主要症状。先前的研究分析了运动开始时与事件相关的不同步，将这两种症状与β频率范围的病理性振荡增加联系起来。然而，由于只关注运动的开始，这些研究不能阐明振荡活动在连续运动中是如何改变的问题。为了研究这一问题，我们比较了13例特发性PD患者在植入深部脑刺激（DBS）电极期间，在休息、前臂等距保持状态和握拳屈伸任务时，丘脑下核（STN）内和上方的局部场电位（LFP）的功率。在握拳屈伸期间（相对于休息），在STN内观察到低β (12-18 Hz)和γ (30-48 Hz)频率范围的活动显著增加，而在握拳期间（与休息相比）没有发现显著差异。对于STN以上的区域，拳头运动时的能量（与休息时相比）明显更高，即在18-30赫兹的范围内，伽马频率范围没有显著变化。β活动被认为会抑制运动，因此会使拳头运动更加疲惫。因此，在拳头运动中观察到的STN β活性的增加可能导致许多患者经历的运动迟缓。我们假设，尽管β活动增加，为了使重复的拳头运动，“促动力学”γ活动可能作为一种补偿机制而增加。(c) 2013 ibro。Elsevier Ltd.出版。版权所有。
Akinesia and rigidity are cardinal symptoms of Parkinson's disease (PD). Previous studies analysing event-related desynchronization during movement onset associated both symptoms with pathologically increased oscillations in the beta frequency range. By focusing on the movement onset only, these studies cannot, however, shed light onto the question how oscillatory activity is changed during continuous movements. To investigate this issue, we compared the power of the local field potentials (LFP) within and above the subthalamic nucleus (STN) during rest, an isometric hold condition of the forearm, and a fist flexion and extension task in 13 patients with idiopathic PD during implantation of deep brain stimulation (DBS) electrodes. During fist flexion and extension (relative to rest), significantly increased activity in the low beta (12-18 Hz) and gamma (30-48 Hz) frequency ranges was observed within the STN, while during hold (compared to rest) no significant difference was found. For the regions above the STN the power during fist movements (compared to rest) was significantly higher, i.e. in the range of 18-30 Hz, with no significant changes in the gamma frequency range. Beta activity is claimed to inhibit movement and thereby could render fist movements more exhausting. Therefore, the observed increase in beta activity in the STN during fist movements might result in bradykinesia as experienced by many patients. We hypothesise that in order to enable repetitive fist movement despite increased beta activity, "prokinetic" gamma activity may be increased as a compensatory mechanism. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.