Effects of estrogen deficiency on tooth movement after force application: an experimental study in ovariectomized rats
Effects of estrogen deficiency on tooth movement after force application: an experimental study in ovariectomized rats
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DOI：
10.1080/00016350701678725
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发表时间：
2007-01-01
影响因子：
2
通讯作者：
Hamamci, Orhan
中科院分区：
文献类型：
--
作者：
Arslan, Seher Guenduez;Arslan, Hueseyin;Hamamci, Orhan
客观的。本研究的目的是探讨雌激素缺乏对卵巢切除大鼠牙齿移动的影响。材料和方法。将42只成年雌性Sprague-Dawley大鼠随机分配至以下组之一：试验组（n=20）、卵巢切除大鼠（或雌激素缺乏大鼠）；对照组（n=22），未切除卵巢的大鼠。卵巢切除后两个月，在两组上中切牙之间插入施加10g力的膨胀弹簧。每天测量移动量，直到牙齿开始移动，然后每隔 3 天测量一次。在施加膨胀弹簧后18天处死大鼠，并沿着左上中切牙根向牙槽骨顶点进行组织形态计量学分析。结果。观察到切除卵巢的大鼠的运动量和运动速度更大。根据组织形态计量学分析，未切除卵巢组压力侧的成骨细胞和骨细胞计数高于卵巢切除组（p < 0.001）。相反，卵巢切除组的破骨细胞计数显着高于非卵巢切除组（p < 0.01）。非卵巢切除组张力侧的成骨细胞和骨细胞计数显着高于卵巢切除组（p < 0.001）。结论。雌激素缺乏会增加正畸牙齿的移动，但在张力和压力区域，负责新骨形成的成骨细胞数量较低。
Objective. The aim of this study was to investigate the effects of estrogen deficiency on tooth movement in ovariectomized rats. Material and methods. Forty-two adult female Sprague-Dawley rats were assigned at random to one of the following groups: test group (n=20), ovariectomized rats (or estrogen-deficient rats); control group (n=22), non-ovariectomized rats. Two months after ovariectomy, expansion springs exerting 10 g of force were inserted between the upper central incisors in both groups. The amount of movement was measured daily until tooth movement began and then at intervals of 3 days. The rats were sacrificed 18 days after applying the expansion spring and histomorphometric analysis was performed along the left upper central incisor root towards the apex of the alveolar bone. Results. The amount and speed of movement was observed to be greater in ovariectomized rats. On histomorphometric analysis, osteoblast and osteocyte counts on the pressure side were higher in the non-ovariectomized group than in the ovariectomized group (p < 0.001). In contrast, the osteoclast count was significantly higher (p < 0.01) in the ovariectomized group than in the non-ovariectomized group. The osteoblast and osteocyte counts were significantly higher (p < 0.001) on tension side in the non-ovariectomized group than in the ovariectomized group. Conclusion. Estrogen deficiency increased orthodontic tooth movements but counts of osteoblasts, which are responsible for new bone formation, were lower in regions of tension and of pressure.