Respiratory muscles and motoneurons.
Respiratory muscles and motoneurons.
复制标题
呼吸肌和运动神经元。
DOI：
10.1016/j.resp.2011.06.027
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发表时间：
2011
影响因子：
2.3
通讯作者：
Fuller,DavidD
中科院分区：
文献类型：
--
作者：
Fregosi,RalphF;Bailey,EFiona;Fuller,DavidD
In this Special Issue of Respiratory Physiology & Neurobiology we seek to draw attention to respiratory muscles and motoneurons, including how they are recruited during respiratory and non-respiratory tasks, and how they develop. Although the content favors consideration of fundamental scientific issues, there is considerable information on system responses, including one review that describes how hypoglossal motoneurons are being used as a model to address motoneuron pathology. The common thread arising from this collection of articles is that we know remarkably little about the mechanism/s by which respiratory muscle motoneurons are recruited during breathing. This deficiency is due in large part to the challenges of recording from respiratory pump and upper airway muscles in behaving human subjects, but nonetheless continues to hamper the translation of findings obtained in animal preparations to the bedside; a challenge that we suggest can only be overcome by attracting young physician scientists to the field.Our current knowledge of respiratory motoneuron physiology, even in reduced animal models, is derived primarily from the study of phrenic and hypoglossal motoneurons. Comparatively little work has been done on other inspiratory and especially expiratory muscle motoneuron pools. However, even within the well-studied phrenic and hypoglossal motoneuron pools, some key questions remain. For example, many investigators have considered the hypoglossal system to be a homogenous motoneuron pool despite the fact that this motor nucleus supplies drive to seven different muscles in the mammal tongue. In addition, the physiologic mechanisms determining respiratory motoneuron recruitment order
