Post-translational control by carrier availability of amino acid transport in fetal human fibroblasts.
Post-translational control by carrier availability of amino acid transport in fetal human fibroblasts.
复制标题
胎儿成纤维细胞中氨基酸转运载体可用性的翻译后控制。
DOI：
10.1016/0006-291x(84)91429-3
复制
发表时间：
1984
影响因子：
3.1
通讯作者：
G. Guidotti
中科院分区：
文献类型：
--
作者：
G. Gazzola;V. Dall’Asta;R. Franchi‐Gazzola;O. Bussolati;Nicola Longo;G. Guidotti
The action of serum on the expression of the starvation-enhanced amino acid transport by System A (as a part of the adaptive regulation mechanism) has been studied in cultured fetal human fibroblasts. Serum enhanced L-proline uptake of cells starved in serum-free medium. This effect was rapid, proportional to the amount of pre-existing transporters, insensitive to cycloheximide and kinetically characterized by an increase of transport Vmax. These results can be interpreted to indicate that serum is essential for a vectorial post-translational event leading to insertion of transport proteins into the cell membrane.
