A functional variation in pre-microRNA-196a is associated with susceptibility of esophageal squamous cell carcinoma risk in Chinese Han
A functional variation in pre-microRNA-196a is associated with susceptibility of esophageal squamous cell carcinoma risk in Chinese Han
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pre-microRNA-196a的功能变异与中国汉族食管鳞状细胞癌的易感性相关
DOI：
10.3109/1354750x.2010.505299
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发表时间：
2010-11-01
期刊：
影响因子：
2.6
通讯作者：
Bai, Yun
中科院分区：
文献类型：
--
作者：
Wang, Kai;Guo, Hong;Bai, Yun
microRNAs（miRNAs）是一类非蛋白质编码的小分子RNA，具有肿瘤抑制基因或癌基因的功能。前体miRNA序列中的单核苷酸变化可以影响miRNA的表达，因此前体miRNA中的单核苷酸多态性（SNP）可能是生物医学应用的生物标志物。在这项研究中，我们进行了一项病例对照研究中，前miRNA-196 a的SNP（rs 11614913）与食管鳞状细胞癌（ESCC）易感性之间的遗传关联研究。我们发现，与纯合子TT相比，该SNP的纯合子CC增加了ESCC的风险，并且吸烟者的风险比非吸烟者更明显。因此，这种功能性SNP可能是ESCC结局的生物标志物。
MicroRNAs (miRNAs) are small, non-protein-coding RNAs that function as tumour suppressors or oncogenes. A single nucleotide change in the sequence of pre-miRNA can affect miRNA expression, so single-nucleotide polymorphisms (SNPs) in pre-miRNA may be biomarkers for biomedical applications. In this study, we performed a genetic association study between the SNP (rs11614913) in pre-miRNA-196a and esophageal squamous cell carcinoma (ESCC) susceptibility in a case–control study. We found that the homozygote CC of this SNP increased the risk of ESCC compared with the homozygote TT and the risk was more evident among smokers than non-smokers. Therefore, this functional SNP may be a biomarker for ESCC outcome.