Complete regression of breast tumour with a single dose of docetaxel-entrapped core-cross-linked polymeric micelles
Complete regression of breast tumour with a single dose of docetaxel-entrapped core-cross-linked polymeric micelles
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DOI：
10.1016/j.biomaterials.2015.02.085
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发表时间：
2015-06-01
期刊：
影响因子：
14
通讯作者：
Prakash, Jai
中科院分区：
文献类型：
--
作者：
Hu, Qizhi;Rijcken, Cristianne J.;Prakash, Jai
Treatment with chemotherapy such as docetaxel (DIX) is associated with significant toxicity and tumour recurrence. In this study, we developed DTX-entrapped core-cross-linked polymeric micelles (DTX-CCL-PMs, 66 nm size) by covalently conjugating DTX to CCL-PMs via a hydrolysable ester bond. The covalent conjugation allowed for sustained release of DTX under physiological conditions in vitro. In vivo, DTX-CCL-PMs demonstrated superior therapeutic efficacy in mice bearing MDA-MB-231 tumour xenografts as compared to the marketed formulation of DTX (Taxotere (R)). Strikingly, a single intravenous injection of DTX-CCL-PMs enabled complete regression of both small (similar to 150 mm(3)) and established (similar to 550 mm(3)) tumours, leading to 100% survival of the animals. These remarkable antitumour effects of DTX-CCL-PMs are attributed to its enhanced tumour accumulation and anti-stromal activity. Furthermore, DTX-CCL-PMs exhibited superior tolerability in healthy rats as compared to Taxotere. These preclinical data strongly support clinical translation of this novel nanomedicinal product for the treatment of cancer. (C) 2015 Elsevier Ltd. All rights reserved.
