Screening of plant constituents for effect on glucose transport activity in Ehrlich ascites tumour cells.
Screening of plant constituents for effect on glucose transport activity in Ehrlich ascites tumour cells.
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筛选植物成分对艾利希腹水肿瘤细胞中葡萄糖转运活性的影响。
DOI：
10.1248/cpb.41.2129
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发表时间：
1993
影响因子：
1.7
通讯作者：
Kazuo Yamasaki
中科院分区：
文献类型：
--
作者：
C. Murakami;Keiko Myoga;R. Kasai;K. Ohtani;Tomonori Kurokawa;Sadahiko Ishibashi;Fabian M. Dayrit;W. Padolina;Kazuo Yamasaki
研究了植物提取物对艾利希腹水肿瘤细胞摄取 D-葡萄糖的影响。 23种药用植物提取物中，5个样品抑制，6个样品激活，摄取显着。从一种活性植物紫薇中分离出两种三萜类化合物：山楂酸和山楂酸。 Colosolic Acid 被证明是一种葡萄糖转运激活剂。由于已知该化合物具有降血糖活性，因此我们简单的体外生物测定方法至少可以用作抗糖尿病活性的初步筛选。
The effect of plant extracts on D-glucose uptake by Ehrlich ascites tumour cells was examined. Among the 23 extracts of medicinal plants, five samples inhibited, and six samples activated, the uptake significantly. From one of the active plants, Lagerstroemia speciosa, two triterpenoids, colosolic acid and maslinic acid were isolated. Colosolic acid was shown to be a glucose transport activator. Since this compound was known to have hypoglycemic activity, our simple in vitro bioassay method can at least be used as a first screening for anti-diabetic activity.