Burns, bacterial translocation, gut barrier function, and failure
Burns, bacterial translocation, gut barrier function, and failure
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DOI：
10.1097/01.bcr.0000176878.79267.e8
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发表时间：
2005-09-01
期刊：
影响因子：
--
通讯作者：
Deitch, EA
中科院分区：
文献类型：
--
作者：
Magnotti, LJ;Deitch, EA
严重烫伤后发生全身炎症、急性肺损伤和多器官衰竭，以及非热形式的创伤，仍然是导致发病率和死亡率的相对常见的原因。在过去的二十年里，越来越多的人认识到肠道缺血可能导致烧伤患者以及其他危重患者发生脓毒症和器官衰竭，这导致了新的假说来解释烧伤引起的多器官衰竭，并强调了早期肠内营养的重要性。因此，这篇综述的目的将是为全身炎症和远处器官功能障碍的肠道假说的演变提供一个视角。
The development of systemic inflammation, acute lung injury, and multiple organ failure after a major thermal injury, as well as nonthermal forms of trauma, remain relatively common causes of morbidity and mortality. During the past two decades, increasing recognition that the ischemic gut may contribute to the development of sepsis and organ failure in burn patients, as well as other critically ill patient populations, has led to new hypotheses to explain burn-induced multiple organ failure as well as highlighted the importance of early enteral nutrition. Thus, the goal of this review will be to provide a perspective on the evolution of the gut hypothesis of systemic inflammation and distant organ dysfunction.