CHOLINERGIC AND INHIBITORY SYNAPSES IN A PATHWAY FROM MOTOR-AXON COLLATERALS TO MOTONEURONES
CHOLINERGIC AND INHIBITORY SYNAPSES IN A PATHWAY FROM MOTOR-AXON COLLATERALS TO MOTONEURONES
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DOI：
10.1113/jphysiol.1954.sp005226
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发表时间：
1954-01-01
影响因子：
5.5
通讯作者：
KOKETSU, K
中科院分区：
文献类型：
--
作者：
ECCLES, JC;FATT, P;KOKETSU, K
猫S脊髓腰段运动神经元的细胞内记录为Renshaw(1941年)发现的逆行抑制效应提供了令人满意的解释。据推测，神经元间的激活是通过运动轴突侧支发生的。经脊髓动脉血供注射乙酰胆碱，造成Renshaw细胞反复点燃。Eserine可提高敏感性，二氢-β-赤霉胺则可抑制敏感性。运动神经元的逆行抑制潜力是通过Renshaw细胞的调节产生的。二氢β-乙二胺抑制和缩短细胞放电，抗胆碱酯酶延长细胞放电，伴随着抑制电位的相应变化。提出的解剖路径被显示出来。运动轴突支汇聚，与Renshaw细胞进行突触接触，Renshaw细胞的轴突汇聚，在相同节段水平与运动神经元进行突触接触。Renshaw细胞集中在腹角的腹内侧区，并向背侧向运动神经元发出轴突。反向截击产生的重复尖峰最初是如此同步，以至于它们融合在一起，以大约1000秒的速度产生有节奏的势波。
Intracellular recordings from motoneurones in lumbar region of cat''s spinal cord provide a satisfactory explanation for the antidromic inhibitory effect discovered by Renshaw (1941). It is postulated that the activation of interneurones takes place via collaterals of motor axons. Renshaw cells were caused to fire repetitively by administration of acetylcholine via arterial blood supply of spinal cord. Sensitivity is increased by eserine and depressed by dihydro-beta-erythroidine. Antidromic inhibitory potential of motoneurones is produced through mediation of Renshaw cells. Depression and shortening of cell discharge by dihydro-beta-erythroidine and its prolongation by anticholinesterases are accompanied by corresponding changes in inhibitory potential. The proposed anatomical pathway is shown. Motor-axon collaterals converge to make synaptic contacts with Renshaw cells whose axons in turn converge to make synaptic contacts with motoneurones at same segmental level. Renshaw cells are concentrated in ventro-medial zone of ventral horn and send their axons dorso-laterally towards motoneurones. Repetitive spikes which an antidromic volley generates are initially so well synchronized that they fuse to give a rhythmic potential wave at about 1000/sec.