Rating the presence and severity of opiate dependence
Rating the presence and severity of opiate dependence
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评估阿片依赖的存在和严重程度
DOI：
10.1002/cpt1974164653
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
Byung L. Roh
中科院分区：
文献类型：
--
作者：
Richard I. H. Wang;Richard L. Wiesen;Sofian Lamid;Byung L. Roh
通过肌内注射0.8 mg纳洛酮并主要通过戒断体征的存在和出现时间评估依赖性的严重程度，检查了对麻醉药品依赖性的评级和确定身体依赖性严重程度的方法。反应进行了研究，在75例药物滥用问题。纳洛酮或生理盐水双盲随机给药。在美沙酮和阿片类药物依赖的受试者中，纳洛酮治疗后的净戒断评分与生理盐水治疗后的净戒断评分显著不同。在非阿片类药物依赖患者中，纳洛酮和生理盐水治疗后的净评分无显著差异。研究结果得到交叉研究的证实，在该研究中，4例疑似阿片类药物依赖患者接受了纳洛酮和生理盐水给药。
The means for rating dependence to narcotic drugs and determining the severity of physical dependence is examined, using the administration at 0.8 mg naloxone intramuscularly and assessing the severity of dependence mainly by the presence and time of appearance of withdrawal signs. Responses were studied in 75 patients with drug abuse problems. Naloxone or saline was administered double blind and at random. In methadone‐ and opiate‐dependent sub;ects, net withdrawal scores after naloxone differed significantly from those after saline. In nonopiate‐dependent patients, there was no significant difference between net scores after naloxone and after saline. The results at the investigation were confirmed by a crossover study in which naloxone and saline were administered to 4 patients with suspected opiate dependence.