Glycinergic/GABAergic synapses in the lateral superior olive are excitatory in neonatal C57Bl/6J mice
Glycinergic/GABAergic synapses in the lateral superior olive are excitatory in neonatal C57Bl/6J mice
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DOI：
10.1016/s0165-3806(01)00271-1
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发表时间：
2001-11-26
期刊：
影响因子：
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通讯作者：
Kandler, K
中科院分区：
文献类型：
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作者：
Kullmann, PHM;Kandler, K
外侧上级橄榄核（LSO）是参与声音定位的核团，接受来自斜方体内侧核（MNTB）的音调组织的抑制性输入。为了更好地理解这种甘氨酸能/GABA能通路的发展，我们使用短杆菌肽穿孔膜片钳记录来表征新生C57 Bl/6 J小鼠LSO神经元中MNTB诱发的突触后电位。我们发现，在出生后的第一周，MNTB诱发的反应从去极化变为超极化。最有趣的是，去极化甘氨酸能/GABA能突触电位能够触发动作电位，表明MNTB-LSO通路可以作为真正的兴奋性通路。未成熟的MNTB-LSO突触的这种短暂兴奋作用可能在LSO抑制性连接的tonotopic组织的活性依赖性锐化中发挥重要作用。(C)2001 Elsevier Science B. V.保留所有权利。
The lateral superior olive (LSO), a nucleus involved in sound localization, receives tonotopically organized, inhibitory input from the medial nucleus of the trapezoid body (MNTB). To better understand the development of this glycinergic/GABAergic pathway, we used Gramicidin-perforated patch clamp recordings to characterize MNTB-evoked postsynaptic potentials in LSO neurons of neonatal C57Bl/6J mice. We found that during the first postnatal week, MNTB-evoked responses change from being depolarizing to being hyperpolarizing. Most interestingly, depolarizing glycinergic/GABAergic synaptic potentials were able to trigger action potentials, demonstrating that the MNTB-LSO pathway can act as a true excitatory pathway. This transient excitatory action of immature MNTB-LSO synapses might play an important role in activity-dependent sharpening of the tonotopic organization of inhibitory connections in the LSO. (C) 2001 Elsevier Science B.V. All rights reserved.