MMN-Indexed Auditory Change Detection in Major Depressive Disorder
MMN-Indexed Auditory Change Detection in Major Depressive Disorder
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DOI：
10.1177/1550059420914200
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发表时间：
2020-04-28
影响因子：
2
通讯作者：
Fisher, Derek J.
中科院分区：
文献类型：
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作者：
Bissonnette, Jenna N.;Francis, Ashley M.;Fisher, Derek J.
在重度抑郁障碍(MDD)患者中，涉及听觉皮质功能的事件相关电位(即N100和P300)往往潜伏期较长，波幅较低。听觉失配负波(MMN)被认为是由听觉皮质和额叶的发生器产生的。关于MDD患者MMN差异的报道各不相同。有人假设，文献中广泛的结果可能是由于在诱导MMN时使用了不同的偏离类型。为了尝试和解释这些不一致，本研究使用了一个多特征MMN范式，在社区居民中使用了5种不同的语调类型，诊断为MDD。我们发现，那些患有MDD的人在强度和位置偏离的音调后有更高的MMN幅度，但其他因素引起的MMN没有差异(相对于未受影响的对照组)。位置MMN偏差与抑郁严重程度评分(即MMN越大，病情越严重)呈负相关。我们还发现，在音高偏差之后，MMN潜伏期更长。这些结果表明，MDD患者早期的听觉变化检测过程发生了改变，但仅遵循某些类型的听觉刺激。对这些发现的可能解释，包括高度焦虑和色氨酸的影响进行了探索。同样，当前的报告强调了在临床人群中检查MMN时使用各种异常类型的重要性。
In major depressive disorder (MDD), event-related potentials that are involved in auditory cortex function (i.e. N100 and P300) often have greater latencies and decreased amplitudes. The auditory mismatch negativity (MMN) is thought to be produced by generators in the auditory cortex, as well as the frontal lobes. Reports on differences in MMN in those with MDD have been varied. It was hypothesized that the wide range of results in the literature may be due to the use of different deviant types in eliciting the MMN. To attempt and explain these inconsistencies, the current study employed a multifeature MMN paradigm with 5 deviant tone types in community-dwelling participants with a diagnosis of MDD. We found those with MDD had higher MMN amplitudes following tones that deviated in intensity and location, but no difference in MMNs elicted by the other deivants (relative to unaffected controls). Location MMN deviants were negatively correlated with depression severity scores (i.e. larger MMN with greater severity). We also found longer MMN latencies following the pitch deviant. These results suggest the early auditory change detection process is altered in MDD, but only following certain types of auditory stimuli. Potential explanations for these findings, including high levels of anxiety and the influence of tryptophan are explored. Equally, the current report highlights the importance of using various deviant types when examining the MMN in clinical populations.