Daphhimalenine A, a New Alkaloid with an Unprecedented Skeleton, from Daphniphyllum himalense
Daphhimalenine A, a New Alkaloid with an Unprecedented Skeleton, from Daphniphyllum himalense
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Daphhimalenine A，一种来自喜马拉雅瑞香的新生物碱，具有前所未有的骨架
DOI：
10.1021/ol902262g
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发表时间：
2009-12-03
期刊：
影响因子：
5.2
通讯作者：
Hao, Xiao-Jiang
中科院分区：
文献类型：
--
作者：
Zhang, Yu;Di, Ying-Tong;Hao, Xiao-Jiang
Daphhimalenine A（1）是一种新的生物碱，具有重排的C-21骨架，含有独特的1-氮杂双环[5.2.1]癸烷环系统，沿着生物学上相关的生物碱daphhimalenine B（2）和daphnezomine T。根据光谱数据确定了它们的结构，并通过计算方法确定了1的绝对构型。还提出了一个合理的生物合成途径1。
Daphhimalenine A (1), a novel alkaloid with a rearrangement C-21 skeleton, containing a unique 1-azabicyclo[5.2.1]decane ring system, was isolated from the leaves of Daphniphyllum himalense, along with biogenetically related alkaloids daphhimalenine B (2) and daphnezomine T. Their structures were established on the basis of spectroscopic data, and the absolute configuration of 1 was assigned by computational methods. A plausible biosynthetic pathway of 1 was also proposed.