MicroRNAs as potential therapeutics for treating spinal cord injury.
MicroRNAs as potential therapeutics for treating spinal cord injury.
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MicroRNA 作为治疗脊髓损伤的潜在疗法
DOI：
10.3969/j.issn.1673-5374.2012.17.011
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发表时间：
2012-06-15
影响因子：
6.1
通讯作者：
Li H
中科院分区：
文献类型：
--
作者：
Yan H;Hong P;Jiang M;Li H
MicroRNA是近年来发现的一类小的非编码RNA，已被证明在绝大多数生物过程中发挥重要作用。关于microRNA在脊髓损伤中的作用知之甚少。本文就脊髓损伤后microRNA表达水平的变化作一综述。这些异常变化表明microRNA在炎症、氧化应激、细胞凋亡、胶质瘢痕形成和轴突再生中起重要作用。鉴于它们的小尺寸和特异性，microRNA可能是未来治疗脊髓损伤的潜在疗法。有快速发展的技术操纵microRNA水平的动物，我们审查不同的化学修饰和交付策略。这些可以为设计用于临床的有效microRNA递送方案提供平台。
MicroRNAs are a class of recently discovered, small non-coding RNAs that have been shown to play essential roles in a vast majority of biological processes. Very little is known about the role of microRNAs during spinal cord injury. This review summarizes the changes in expression levels of microRNAs after spinal cord injury. These aberrant changes suggest that microRNAs play an important role in inflammation, oxidative stress, apoptosis, glial scar formation and axonal regeneration. Given their small size and specificity of action, microRNAs could be potential therapeutics for treating spinal cord injury in the future. There are rapidly developing techniques for manipulating microRNA levels in animals; we review different chemical modification and delivery strategies. These may provide platforms for designing efficient microRNA delivery protocols for use in the clinic.
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影响因子：
3.8
作者：
Adibhatla RM;Hatcher JF
通讯作者：
Hatcher JF
影响因子：
4.5
作者：
Faller, Michael;Toso, Daniel;Guo, Feng
通讯作者：
Guo, Feng
影响因子：
48
作者：
Gentner, Bernhard;Schira, Giulia;Naldini, Luigi
通讯作者：
Naldini, Luigi
影响因子：
3.5
作者：
Christensen M;Larsen LA;Kauppinen S;Schratt G
通讯作者：
Schratt G
DOI：
10.1158/1940-6207.capr-10-0333
发表时间：
2011-07
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Hao Y;Gu X;Zhao Y;Greene S;Sha W;Smoot DT;Califano J;Wu TC;Pang X
通讯作者：
Pang X