Molecular Genetic Strategies in the Study of Corticohippocampal Circuits.
Molecular Genetic Strategies in the Study of Corticohippocampal Circuits.
复制标题
DOI：
10.1101/cshperspect.a021725
复制
发表时间：
2015-07
影响因子：
7.2
通讯作者：
Christopher C. Angelakos;T. Abel
中科院分区：
文献类型：
--
作者：
Christopher C. Angelakos;T. Abel
第一个生殖可行的遗传修饰小鼠由Richard Palmiter和Ralph Brinster于1982年创建（Palmiter RD，Brinster RL，Hammer RE，Trumbauer ME，Rosenfeld MG，Birnberg NC，Evans RM. 1982.通过显微注射金属硫蛋白-生长激素融合基因的卵子发育的小鼠的显著生长。Nature 300：611-615）。在随后的30多年里，遗传操作方面的许多突破性技术进步为改善空间和时间目标研究铺平了道路。分子遗传学研究对于探索生物体如何学习和记忆的分子和电路特别有用，这是神经科学研究中最有趣和深入研究的问题之一。在这里，我们讨论了选定的遗传工具，重点是皮质海马电路及其对理解学习和记忆的影响。
The first reproductively viable genetically modified mice were created in 1982 by Richard Palmiter and Ralph Brinster (Palmiter RD, Brinster RL, Hammer RE, Trumbauer ME, Rosenfeld MG, Birnberg NC, Evans RM. 1982. Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature 300: 611-615). In the subsequent 30 plus years, numerous ground-breaking technical advancements in genetic manipulation have paved the way for improved spatially and temporally targeted research. Molecular genetic studies have been especially useful for probing the molecules and circuits underlying how organisms learn and remember—one of the most interesting and intensively investigated questions in neuroscience research. Here, we discuss selected genetic tools, focusing on corticohippocampal circuits and their implications for understanding learning and memory.