A rabbit model of human familial, nonsyndromic unicoronal suture synostosis - II. Intracranial contents, intracranial volume, and intracranial pressure
A rabbit model of human familial, nonsyndromic unicoronal suture synostosis - II. Intracranial contents, intracranial volume, and intracranial pressure
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DOI：
10.1007/s003810050220
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发表时间：
1998-06-01
影响因子：
1.4
通讯作者：
Kapucu, LO
中科院分区：
文献类型：
--
作者：
Mooney, MP;Siegel, MI;Kapucu, LO
本研究分为两部分，回顾了最近开发的一个新西兰白色兔群体的数据，该群体患有家族性、非综合征性单侧冠状缝骨性结合，第二帕雷介绍了该群体106只正常兔和56只颅缝骨性结合兔的神经病理学结果和颅内容积（ICV）和颅内压（ICP）的年龄相关变化。本文描述了44只胎兔和围产期兔（27只正常，17只融合）的脑形态和前后长度。通过2D PCC MRI VENC扫描和颅内描记对15只、126日龄家兔（8只正常，7只患有单冠骨结合）的脑膜中动脉模式进行定性评估。采用高分辨PET显像技术，对7只、25日龄家兔（3只正常，4只单冠或双冠骨性结合）的18F-FDG摄取进行评价。对30只兔（20只正常兔，10只单冠骨性结合兔）42日龄和126日龄的颅骨进行三维CT扫描，测量颅内内容物和ICV。连续ICP数据收集自66只兔（49只正常; 17只患有单冠骨性结合）在25和42日龄。使用Codman NeuroMonitor微传感器传感器在硬膜外腔中评估ICP。结果显示，大脑皮质形态学之间的正常和骨性结合胎儿之间的时间骨性结合是相似的。显著（P
This two-part study reviews data from a recently developed colony of New Zealand white rabbits with familial, nonsyndromic unilateral coronal suture synostosis, and this second pare presents neuropathological findings and age-related changes in intracranial volume (ICV) and intracranial pressure (ICP) in 106 normal rabbits and 56 craniosynostotic rabbits from this colony. Brain morphology and anteroposterior length were described in 44 rabbit fetuses and perinates (27 normal; 17 synostosed). Middle meningeal artery patterns were qualitatively assessed from 2-D PCC MRI VENC scans and endocranial tracings from 15, 126-day-old rabbits (8 normal, 7 rabbits with unicoronal synostosis). Brain metabolism was evaluated by assessing 18F-FDG uptake with high-resolution PET scanning in 7, 25-day-old rabbits (3 normal, 4 with unicoronal or bicoronal synostosis). Intracranial contents and ICV were assessed using 3-D CT scanning of the skulls of 30 rabbits (20 normal,10 with unicoronal synostosis) at 42 and 126 days of age. Serial ICP data were collected from 66 rabbits (49 normal; 17 with unicoronal synostosis) at 25 and 42 days of age. ICP was assessed in the epidural space using a Codman NeuroMonitor microsensor transducer. Results revealed that cerebral cortex morphology was similar between normal and synostosed fetuses around the time of synostosis. Significantly (P