Reduction in thrombotic events with heparin-coated Palmaz-Schatz stents in normal porcine coronary arteries
Reduction in thrombotic events with heparin-coated Palmaz-Schatz stents in normal porcine coronary arteries
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DOI：
10.1161/01.cir.93.3.423
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发表时间：
1996-02-01
期刊：
影响因子：
37.8
通讯作者：
vanderGiessen, WJ
中科院分区：
文献类型：
--
作者：
Hardhammar, PA;vanBeusekom, HMM;vanderGiessen, WJ
背景冠脉球囊成形术后支架的使用提高了治疗效果。然而，支架的血栓形成性是一个值得关注的问题。在本研究中，我们比较了有抗血栓涂层的支架和普通支架。方法与结果在未服用阿司匹林（1组，n=8）或服用阿司匹林4周（2组，n=10）或12周（3组，n=9）的猪冠状动脉内放置常规支架。将肝素包被支架（抗凝血酶III摄取，5 pmol/支架）放置在7只未接受阿司匹林治疗的猪身上（第4组）。其他动物接受阿司匹林和包膜支架治疗，肝素活性为12 pmol/支（第5组，n=10）或20 pmol/支（第6组，n=10；第7组，n=10）。在植入时和植入后4周（1、2、4至6组）或12周（3、7组）进行定量动脉造影。在另外5只动物中，放置5个常规支架和5个涂层支架（20个粘性支架），并在5天后拔出，以检查对植入物的早期反应。1 ~ 3组27例常规支架患者中有9例发生血栓闭塞。然而，在接受高活性肝素包覆支架的30只动物中（5至7组），有0只动物观察到血栓性支架闭塞(P
Background The use of stents improves the result after balloon coronary angioplasty. Thrombogenicity of stents is, however, a concern. In the present study, we compared stents with an antithrombotic coating with regular stents.Methods and Results Regular stents were placed in coronary arteries of pigs receiving no aspirin (group 1; n=8) or aspirin over 4 weeks (group 2, n=10) or 12 weeks (group 3, n=9). Stents coated with heparin (antithrombin III uptake, 5 pmol/stent) were placed in 7 pigs that did not receive aspirin (group 4). The other animals received aspirin and coated stents with a heparin activity of 12 pmol antithrombin III/stent (group 5, n=10) or 20 pmol/stent (group 6, n=10; group 7, n=10). Quantitative arteriography was performed at implantation and after 4 (groups 1, 2, and 4 through 6) or 12 weeks (groups 3 and 7). In an additional 5 animals, five regular and five coated stents (20 pmolistent) were placed and explanted after 5 days for examination of the early responses to the implants. Thrombotic occlusion of the regular stent occurred in 9 of 27 in groups 1 through 3. However, in 0 of 30 of the animals receiving high activity heparin-coated stents (groups 5 through 7), thrombotic stent occlusion was observed (P