Radial cytoarchitecture and patterns of cortical connectivity in autism
Radial cytoarchitecture and patterns of cortical connectivity in autism
复制标题
DOI：
10.1098/rstb.2008.0331
复制
发表时间：
2009-05-27
影响因子：
6.3
通讯作者：
Trippe, Juan
中科院分区：
文献类型：
--
作者：
Casanova, Manuel F.;Trippe, Juan
为了解释在自闭症谱系障碍中发现的保留和上级能力的模式，出现了一种假设，该假设假设认为存在对短程连接形成的发展偏好。这将导致易受影响的本地网络内的过度活动和过度连接。这些网络可能变得部分孤立，并获得新的功能特性。反过来，这将影响到管理自上而下控制和整合的远程电路和系统的形成。尽管有许多诱人的线索，发病机制和改变细胞功能的“断开”的整合和重点活动仍然模糊。然而，最近对自闭症患者大脑的尸检研究表明，放射状细胞微柱的形态特征存在差异，这为连通性假说提供了证据。
To explain the pattern of preserved and superior abilities found in autism spectrum disorders, a hypothesis has emerged, which assumes that there is a developmental bias towards the formation of short-range connections. This would result in excessive activity and overconnectivity within susceptible local networks. These networks might become partially isolated and acquire novel functional properties. In turn, this would affect the formation of long-range circuits and systems governing top-down control and integration. Despite many tantalizing clues, mechanisms relating pathogenesis and altered cell function to the 'disconnection' of integrative and focal activity remain obscure. However, recent post-mortem studies of brains of individuals with autism have shown characteristic differences in the morphometry of radial cell minicolumns, which add credence to the connectivity hypothesis.