URINARY-EXCRETION OF HYDROXY-PYRIDINIUM CROSS-LINKS OF COLLAGEN REFLECTS SKELETAL GROWTH VELOCITY IN NORMAL-CHILDREN
URINARY-EXCRETION OF HYDROXY-PYRIDINIUM CROSS-LINKS OF COLLAGEN REFLECTS SKELETAL GROWTH VELOCITY IN NORMAL-CHILDREN
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DOI：
10.1055/s-0029-1211269
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发表时间：
1994-01-01
期刊：
影响因子：
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通讯作者：
SEIBEL, M
中科院分区：
文献类型：
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作者：
RAUCH, F;SCHONAU, E;SEIBEL, M
在 88 名健康儿童（45 名女性，43 名男性；年龄 4 至 18 岁）和 17 名成人的 24 小时尿液收集中测量了两种新的骨吸收标志物，即胶原交联氨基酸吡啶啉 (PYD) 和脱氧吡啶啉 (DPD)。为这些参数建立了儿科使用的正常值。与肌酐每日排泄相关的 PYD 和 DPD 儿童组比成人高约 3 至 6 倍。胶原交联与尿羟脯氨酸 (OHP) 排泄量 (OHP) 呈高度显着相关：PYD 的 r = 0.65，DPD 的 r = 0.60 (p < 0.001)。与肌酐相关的胶原交联和 OHP 排泄均与生长速度显着相关（PYD、DPD 和 OHP 的 r = 0.67、0.62 和 0.51；每种情况下 p < 0.001）。 PYD 和 DPD 可能有助于监测儿童的生长情况。
Two new markers of bone resorption, the colla,gen cross-linking amino acids pyridinoline (PYD) and deoxypyridinoline (DPD), were measured in 24-h urine collections from 88 healthy children (45 females, 43 males; age 4 to 18 years) and 17 adults. Normal values for pediatric use were established for these parameters. Related to daily excretion of creatinine PYD and DPD were about 3 to 6 fold higher in the pediatric groups than in adults. The collagen cross-links showed a highly significant correlation to the urinary excretion of hydroxyproline (OHP): r = 0.65 for PYD and r = 0.60 for DPD (p < 0.001). Both collagen cross-links and OHP excretion related to creatinine were significantly correlated to growth velocity (r = 0.67, 0.62 and 0.51 for PYD, DPD and OHP respectively; p < 0.001 in each case). PYD and DPD may be useful for the monitoring of growth in children.