Changes in viscoelastic properties of articular cartilage in early stage of osteoarthritis, as determined by optical coherence tomography-based strain rate tomography
Changes in viscoelastic properties of articular cartilage in early stage of osteoarthritis, as determined by optical coherence tomography-based strain rate tomography
复制标题
DOI：
10.1186/s12891-019-2789-4
复制
发表时间：
2019-09-06
影响因子：
2.3
通讯作者：
Nakamura, Hiroaki
中科院分区：
文献类型：
--
作者：
Nakamura, Suguru;Ikebuchi, Mitsuhiko;Nakamura, Hiroaki
背景关节软骨的生物力学变化与骨性关节炎的发生有关。我们发展了一种基于光学相干层析的应变速率层析成像方法：应力松弛光学相干层析技术(SR-OCSA)。本研究的目的是建立一种使用SR-OCSA测量关节软骨力学性能的方法，并探讨早期骨关节炎关节软骨的粘弹性特性的分布。方法8~9月龄新西兰大白兔左膝前交叉韧带横断术。用SR-OCSA通过应变率衰减系数(ACSR)显示和测量关节软骨的粘弹性特性。在与SR-OCSA试验相同的条件下，进行压痕试验，测量松弛时间，以评估ACSR与松弛时间的关系。结果SR-OCSA能无损检测和可视化早期骨性关节炎关节软骨粘弹性分布的变化。SR-OCSA在术后2周发现软骨中ACSR显著增加，此时组织学上有轻微的骨关节炎征象。随着软骨退变的进展，ACSR增加，而松弛时间以时间依赖的方式减少。此外，ACSR与松弛时间呈负相关。特别是，ACSR在潮汐周围升高，并且随着软骨退变的进展，升高倾向于移动。结论SR-OCSA能对早期骨关节炎关节软骨的粘弹性分布进行断层、非破坏性检测和可视化。随着软骨退变的进展，潮标周围的力学性能也随之退化。因此，SR-OCSA为了解早期骨关节炎的生物力学提供了重要的数据。
Background Biomechanical changes in articular cartilage are associated with the onset of osteoarthritis. We developed an optical coherence tomography-based strain rate tomography method: stress relaxation optical coherence straingraphy (SR-OCSA). The purpose of this study was to establish an approach for measuring mechanical properties of articular cartilage using SR-OCSA, and to investigate the distribution of viscoelastic properties of articular cartilage in early osteoarthritis. Methods Anterior cruciate ligament transection surgery was performed on the left knees of 8-9-month-old New Zealand white rabbits. SR-OCSA was used to visualize and measure the viscoelastic properties of articular cartilage via attenuation coefficient of strain rate (ACSR). Using the same conditions as in the SR-OCSA test, an indentation test was conducted, and relaxation time was measured to evaluate the relationship between ACSR and relaxation time. Results SR-OCSA could nondestructively detect and visualize changes in the distribution of viscoelastic properties of articular cartilage in early osteoarthritis. SR-OCSA captured significant increases in ACSR in cartilage at 2 weeks after surgery, when a histologically slight osteoarthritis sign was present. As cartilage degeneration progressed, ACSR increased, whereas relaxation time decreased in a time-dependent manner. Moreover, ACSR negatively correlated with relaxation time. In particular, ACSR was elevated around the tidemark and the elevation tended to move as cartilage degeneration progressed. Conclusions SR-OCSA could tomographically and nondestructively detect and visualize changes in the distribution of viscoelastic properties of articular cartilage in early osteoarthritis. The mechanical properties around the tidemark were degraded as cartilage degeneration progressed. Thus, SR-OCSA provides important data needed to understand the biomechanics of early osteoarthritis.